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1993 1
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1999 2
2000 1
2024 0

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Page 1
Compatibility and stability of aplidine, a novel marine-derived depsipeptide antitumor agent, in infusion devices, and its hemolytic and precipitation potential upon i.v. administration.
Nuijen B, Bouma M, Henrar RE, Manada C, Bult A, Beijnen JH. Nuijen B, et al. Among authors: henrar re. Anticancer Drugs. 1999 Nov;10(10):879-87. doi: 10.1097/00001813-199911000-00003. Anticancer Drugs. 1999. PMID: 10630355
After reconstitution and dilution the drug is stable for at least 24 and 48 h, respectively, in glass containers when stored at room temperature (20-25 degrees C) and ambient light conditions. We found that aplidine should be administered in infusion concentrations equal o …
After reconstitution and dilution the drug is stable for at least 24 and 48 h, respectively, in glass containers when stored at room tempera …
Pharmaceutical development of a parenteral formulation of the investigational anticancer drug clanfenur.
Jonkman-de Vries JD, Van den Bemt BJ, ten Bokkel-Huinink WW, Underberg WJ, Kettenes-van den Bosch JJ, Henrar RE, Bult A, Beijnen JH. Jonkman-de Vries JD, et al. Among authors: henrar re. PDA J Pharm Sci Technol. 1997 Mar-Apr;51(2):89-95. PDA J Pharm Sci Technol. 1997. PMID: 9146040
From accelerated stability testing of clanfenur in the Cremophor EL/ethanol (1:1, w/v) formulation, a shelf life of 3.5 years at 4 degrees C and of 4 months at 25 degrees C is calculated....
From accelerated stability testing of clanfenur in the Cremophor EL/ethanol (1:1, w/v) formulation, a shelf life of 3.5 years at 4 degrees …
Pharmaceutical development of a parenteral formulation of the novel anti-tumor agent carzelesin (U-80,244).
Jonkman-de Vries JD, de Graaff-Teulen MJ, Henrar RE, Kettenes-van den Bosch JJ, Bult A, Beijnen JH. Jonkman-de Vries JD, et al. Among authors: henrar re. Invest New Drugs. 1994;12(4):303-14. doi: 10.1007/BF00873045. Invest New Drugs. 1994. PMID: 7775131
Shelf life studies demonstrated that the formulation is stable for at least 1 year, when stored at -30 degrees C in the dark. In addition, the stability of carzelesin in the PET formulation is discussed as a function of temperature, additives and after dilution in infusion …
Shelf life studies demonstrated that the formulation is stable for at least 1 year, when stored at -30 degrees C in the dark. In addi …
Pharmaceutical development of a parenteral lyophilized formulation of the novel antitumor agent aplidine.
Nuijen B, Bouma M, Henrar RE, Floriano P, Jimeno JM, Talsma H, Kettenes-van den Bosch JJ, Heck AJ, Bult A, Beijnen JH. Nuijen B, et al. Among authors: henrar re. PDA J Pharm Sci Technol. 2000 May-Jun;54(3):193-208. PDA J Pharm Sci Technol. 2000. PMID: 10927911
Shelf-life data, available thus far, show that the lyophilized formulation is stable for at least 1 year when stored at +2-8 degrees C in the dark....
Shelf-life data, available thus far, show that the lyophilized formulation is stable for at least 1 year when stored at +2-8 degrees C …
Analysis of Ecteinascidin 743, a new potent marine-derived anticancer drug, in human plasma by high-performance liquid chromatography in combination with solid-phase extraction.
Rosing H, Hillebrand MJ, Jimeno JM, Gómez A, Floriano P, Faircloth G, Cameron L, Henrar RE, Vermorken JB, Bult A, Beijnen JH. Rosing H, et al. Among authors: henrar re. J Chromatogr B Biomed Sci Appl. 1998 Jun 12;710(1-2):183-9. doi: 10.1016/s0378-4347(98)00143-1. J Chromatogr B Biomed Sci Appl. 1998. PMID: 9686886
The drug was found to be stable in human plasma at -30 degrees C for at least 2 months. At room temperature Ecteinascidin 743 was stable in human plasma for 5 h at most....
The drug was found to be stable in human plasma at -30 degrees C for at least 2 months. At room temperature Ecteinascidin 743 was sta …
EO9: a novel bioreductive alkylating indoloquinone with preferential solid tumour activity and lack of bone marrow toxicity in preclinical models.
Hendriks HR, Pizao PE, Berger DP, Kooistra KL, Bibby MC, Boven E, Dreef-van der Meulen HC, Henrar RE, Fiebig HH, Double JA, et al. Hendriks HR, et al. Among authors: henrar re. Eur J Cancer. 1993;29A(6):897-906. doi: 10.1016/s0959-8049(05)80434-4. Eur J Cancer. 1993. PMID: 8484984
EO9 is a novel and fully synthetic bioreductive alkylating indoloquinone. Although structurally-related to mitomycin C, EO9 exhibits a distinct preclinical antitumour profile and there are also differences in its biochemical activation. ...Considering its distinct mechanis …
EO9 is a novel and fully synthetic bioreductive alkylating indoloquinone. Although structurally-related to mitomycin C, EO9 exhibits …
Pharmaceutical development of a parenteral lyophilized formulation of the investigational antitumor neuropeptide antagonist [Arg6, D-Trp7,9, MePhe8]-Substance P [6-11].
Jonkman-de Vries JD, Rosing H, Talsma H, Henrar RE, Kettenes-van den Bosch JJ, Bult A, Beijnen JH. Jonkman-de Vries JD, et al. Among authors: henrar re. Invest New Drugs. 1998;16(2):99-111. doi: 10.1023/a:1006041024109. Invest New Drugs. 1998. PMID: 9848573
Shelf life studies demonstrated that the formulation is stable for at least 3 years, when stored at 2-8 degrees C in a dark environment. Oxidative degradation products of Antagonist G were isolated and structurally characterized by mass spectrometry, nuclear magnetic reson …
Shelf life studies demonstrated that the formulation is stable for at least 3 years, when stored at 2-8 degrees C in a dark environme …
Bioanalysis of thiocoraline, a new marine antitumoral depsipeptide, in plasma by high-performance liquid chromatography and fluorescence detection.
Sparidans RW, Henrar RE, Jimeno JM, Faircloth G, Floriano P, Beijnen JH. Sparidans RW, et al. Among authors: henrar re. J Chromatogr B Biomed Sci Appl. 1999 Apr 16;726(1-2):255-60. doi: 10.1016/s0378-4347(99)00062-6. J Chromatogr B Biomed Sci Appl. 1999. PMID: 10348193
Plasma samples can be stored for at least 4 months at -80 degrees C. Finally, the usefulness of this method for pharmacological research was shown in a pilot study of the pharmacokinetics of thiocoraline in rats....
Plasma samples can be stored for at least 4 months at -80 degrees C. Finally, the usefulness of this method for pharmacological resea …
Pharmaceutical development of a parenteral lyophilized formulation of the novel indoloquinone antitumor agent EO9.
Jonkman-de Vries JD, Talsma H, Henrar RE, Kettenes-van den Bosch JJ, Bult A, Beijnen JH. Jonkman-de Vries JD, et al. Among authors: henrar re. Cancer Chemother Pharmacol. 1994;34(5):416-22. doi: 10.1007/BF00685567. Cancer Chemother Pharmacol. 1994. PMID: 8070009
Shelf-life studies demonstrated that the formulation remains stable for at least 1 year when stored at +4 degrees C in a dark environment....
Shelf-life studies demonstrated that the formulation remains stable for at least 1 year when stored at +4 degrees C in a dark environ …