This paper discusses polyvinylidene fluoride (PVDF) as an alternative to stainless steel in pharmaceutical ultrapure water piping systems. Two leading Swiss companies, a piping systems supplier and a pharmaceutical manufacturer, teamed together to jointly carryout the research. Issues addressed are metallic contamination, microbial concerns, piping system functionally and ozone resistance. Comparisons between PVDF and stainless steel are made when necessary.