Capping completes the closure of parenteral drug products in the final packaging container
and is critical in maintaining an integral seal to ensure product quality. Residual seal force …

As the complexities of the pharmaceuticals needed to prevail over serious diseases
continue to grow, the need for technologies to enable their efficient storage and delivery are …

A drug delivery system is designed to administer a therapeutic dose according to its label
claim. Upon delivery of a parenteral drug product, the volume remaining inside the container …

A vial-capping process for lyophilization stopper configurations was previously quantified
using residual seal force (RSF). A correlation between RSF and container closure integrity …

Vial capping plays a critical role in the drug product manufacturing process owing to the
complex interplay of several adjustable process steps. Seal quality and integrity and …

For lyophilization applications, the selection of the primary container system (ie vial, stopper,
seal) must be given careful consideration in order to avoid surprises in the later stages of …

Container closure integrity (CCI) is one of the requirements for a sterile packaging system.
For vial-based systems, the capping process is a critical step in creating and ensuring an …

This internship was conducted in Hikma, which is a pharmaceutical company located in
Sintra, Portugal responsible for the production of injectables for the Portuguese and …