Near infrared (NIR) spectroscopy has the capability of providing real‐time, multi‐analyte
monitoring of the complex reaction mixture associated with cell culture processes. However, the …

Over the past decade, Cell and Gene Therapies (C>) have been an emerging therapeutic
area with more than twenty C> drug products approved and over 1000 registered trials. The …

This chapter reviews research on existing and new sampling and sensor technologies for
monitoring fermentations and mammalian cell culture in the last decade. New technologies are …

Monitoring of cell culture bioreactors is critical to process control and optimization. Currently,
offline sampling is used in various cell culture operations. This process is time consuming …

Cleaning validation acceptance criteria in multiproduct facilities are established using
maximum allowable carryover calculations. Carryover calculations incorporate the shared …

The last decade has shown significant progress in understanding the impact of the cellular
environment on culture physiology and its subsequent impact on productivity, product quality …

… Michael Parks, Niamh O'Dwyer, Jeremy Bollinger, Alan Johnson, Brian Goss, Ned
Wyman, Adeyma Arroyo, Joseph Wood and Derek Willison-Parry …

A rich array of methods and discussions of productive microbial processes.• Reviews of the
newest techniques, approaches, and options in the use of microorganisms and other cell …