A controlled drug delivery system with prolonged residence time in the stomach is of particular
interest for drugs that i) are locally active in the stomach, ii) have an absorption window in …

The bioavailability of drugs with an absorption window in the upper small intestine is
generally limited with conventional pharmaceutical dosage forms. The residence time of such …

Purpose. The objectives of this work were (i) to study and understand the physicochemical
phenomena which are involved in the swelling and drug release from hydrophilic matrix …

The vial capping process is a critical unit operation during drug product manufacturing, as it
could possibly generate cosmetic defects or even affect container closure integrity. Yet there …

Capping completes the closure of parenteral drug products in the final packaging container
and is critical in maintaining an integral seal to ensure product quality. Residual seal force (…

Parenteral drug products are protected by appropriate primary packaging to protect against
environmental factors, including potential microbial contamination during shelf life duration. …

Capping equipment used in good manufacturing practice manufacturing features different
designs and a variety of adjustable process parameters. The overall capping result is a …

The majority of parenteral drug products are manufactured in glass vials with an elastomeric
rubber stopper and a crimp cap. The vial sealing process is a critical process step during fill-…

Parenteral container closure systems are in direct contact with the drug product formulation
and can significantly impact the product quality. The interaction between the drug product …

Capping equipment used in good manufacturing practice (GMP) manufacturing feature different
designs and a variety of adjustable process parameters. The overall capping result is a …