A comprehensive stability-indicating HPLC method for determination of chloroquine in active pharmaceutical ingredient and tablets: identification of oxidation …

AS Coelho, CEP Chagas, RM de Pádua… - … of Pharmaceutical and …, 2017 - Elsevier
Malaria is the most common parasitic disease in humans. It is estimated that 3 billion people
live under the risk of contracting this disease in the world. Chloroquine (CQ) is the drug of …

Mannosylerythritol lipids: antimicrobial and biomedical properties

ALS Coelho, PE Feuser, BAM Carciofi… - Applied microbiology …, 2020 - Springer
Mannosylerythritol lipids (MELs) have attracted particular interest of medical, pharmaceutical,
and cosmetic fields, due to their specific characteristics, including non-toxicity, easy …

Immobilized microbial lipases in the food industry: A systematic literature review

ALS Coelho, RC Orlandelli - Critical Reviews in Food Science and …, 2021 - Taylor & Francis
Several studies describe the immobilization of microbial lipases aiming to evaluate the
mechanical/thermal stability of the support/enzyme system, the appropriate method for …

[HTML][HTML] Safety and efficacy of RNAi therapy for transthyretin amyloidosis

T Coelho, D Adams, A Silva, P Lozeron… - … England Journal of …, 2013 - Mass Medical Soc
Background Transthyretin amyloidosis is caused by the deposition of hepatocyte-derived
transthyretin amyloid in peripheral nerves and the heart. A therapeutic approach mediated by …

Exosomes secreted by cardiomyocytes subjected to ischaemia promote cardiac angiogenesis

…, R Pereira, V Coelho-Santos, AP Silva… - Cardiovascular …, 2017 - academic.oup.com
Aims Myocardial infarction (MI) is the leading cause of morbidity and mortality worldwide
and results from an obstruction in the blood supply to a region of the heart. In an attempt to …

[HTML][HTML] The population genomics of archaeological transition in west Iberia: Investigation of ancient substructure using imputation and haplotype-based methods

…, L Manco, D Fidalgo, T Pereira, MJ Coelho… - PLoS …, 2017 - journals.plos.org
We analyse new genomic data (0.05–2.95x) from 14 ancient individuals from Portugal
distributed from the Middle Neolithic (4200–3500 BC) to the Middle Bronze Age (1740–1430 BC) …

[HTML][HTML] A narrative review of motor competence in children and adolescents: What we know and what we need to find out

L Lopes, R Santos, M Coelho-e-Silva, C Draper… - International journal of …, 2021 - mdpi.com
Lack of physical activity is a global public health problem causing not only morbidity and
premature mortality, but it is also a major economic burden worldwide. One of the cornerstones …

[HTML][HTML] Fermentation box cleaning can impair cacao seed fermentation

…, MPM Oliveira, LH Gomes, IS Coelho… - Food Science and …, 2023 - SciELO Brasil
The quality of the raw material for chocolate manufacture depends on the control of cacao
seed fermentation. Practices affect the diversity and metabolic activities of spontaneous yeasts …

Quality of life experienced by adolescents and young adults with congenital heart disease

FM Teixeira, RM Coelho, C Proença, AM Silva… - Pediatric …, 2011 - Springer
This study aimed to assess the quality of life (QOL) experienced by adolescents and young
adults with congenital heart disease (CHD) and to determine which factors negatively affect …

The TNF-α/Nf-κB Signaling Pathway has a Key Role in Methamphetamine–Induced Blood–Brain Barrier Dysfunction

V Coelho-Santos, RA Leitão… - Journal of Cerebral …, 2015 - journals.sagepub.com
Methamphetamine (METH) is a psychostimulant that causes neurologic and psychiatric
abnormalities. Recent studies have suggested that its neurotoxicity may also result from its ability …