Many plant and animal bacterial pathogens assemble a needle-like nanomachine, the type
III secretion system (T3SS), to inject virulence proteins directly into eukaryotic cells to initiate …

β-sheet proteins carry out critical functions in biology, and hence are attractive scaffolds for
computational protein design. Despite this potential, de novo design of all-β-sheet proteins …

Degradation of the surfactant polysorbate (PS) by enzyme impurities has been previously
suggested as a mechanism for the formation of visible and subvisible particles that affect …

Chaperones TAPBPR and tapasin associate with class I major histocompatibility complexes
(MHC-I) to promote optimization (editing) of peptide cargo. Here, we use solution NMR to …

The molecular mechanism through which the interaction of a clonotypic αβ T-cell receptor (TCR)
with a peptide-loaded major histocompatibility complex (p/MHC) leads to T-cell …

Chaperones tapasin and transporter associated with antigen processing (TAP)-binding
protein related (TAPBPR) associate with the major histocompatibility complex (MHC)-related …

Antigen presentation is a cellular process that involves a number of steps, beginning with the
production of peptides by proteolysis or aberrant synthesis and the delivery of peptides to …

The lasting threat of viral pandemics necessitates the development of tailorable first-response
antivirals with specific but adaptive architectures for treatment of novel viral infections. Here…

Chemical shifts are highly sensitive probes harnessed by NMR spectroscopists and structural
biologists as conformational parameters to characterize a range of biological molecules. …

Chaperones Tapasin and TAP-binding protein related (TAPBPR) perform the important
functions of stabilizing nascent MHC-I molecules (chaperoning) and selecting high-affinity …