Defects in motile cilia and sperm flagella cause primary ciliary dyskinesia (PCD), characterized
by chronic airway disease, infertility, and left-right body axis disturbance. Here we report …

Malignant hyperthermia (MH) is an autosomal dominant disorder characterized by abnormal
calcium homeostasis in skeletal muscle in response to triggering agents. Today, genetic …

Monoubiquitination of histone H2B lysine 123 regulates methylation of histone H3 lysine 4 (H3K4)
and 79 (H3K79) and the lack of H2B ubiquitination in Saccharomyces cerevisiae …

BRE1 encodes an E3 ubiquitin protein ligase that is required for the ubiquitylation of histone
H2B at lysine 123 (K123). Ubiquitylation of this histone residue is involved in a variety of …

Prefilled syringes (PFSs) are increasingly preferred over vials as container closure systems (CCSs)
for injectable drug products when facilitated or self-administration is required. …

The phase-appropriate application of analytical methods to characterize, monitor, and control
particles is an important aspect of the development of safe and efficacious biotherapeutics. …

The sterility of drug products intended for parenteral administration is a critical quality attribute
(CQA) because it serves to ensure patient safety and is thus a key requirement by health …

Subvisible particles (SVPs) are an obligatory critical quality attribute of the product, and yet,
they are found in all biopharmaceutical products intended for infusion or injection. Light …

Purpose Health care professionals can be exposed to hazardous drugs such as cytostatics
during preparation of drugs for administration. Closed sytem transfer devices (CSTDs) were …

The measurement of polydisperse protein aggregates and particles in biotherapeutics
remains a challenge, especially for particles with diameters of ≈ 1 µm and below (sub-micrometer…