[HTML][HTML] Microplastics profile along the Rhine River

T Mani, A Hauk, U Walter, P Burkhardt-Holm - Scientific reports, 2015 - nature.com
Microplastics result from fragmentation of plastic debris or are released to the environment
as pre-production pellets or components of consumer and industrial products. In the oceans, …

Measurement of triclosan in wastewater treatment systems

…, B Schatowitz, M Jacob, A Hauk… - … and Chemistry: An …, 2002 - Wiley Online Library
The objective of this study was to investigate the fate and removal of triclosan (TCS; 5‐chloro‐2‐[2,4‐dichloro‐phenoxy]‐phenol),
an antimicrobial agent used in a variety of household …

Environmental fate of triclosan in the River Aire Basin, UK

D Sabaliunas, SF Webb, A Hauk, M Jacob, WS Eckhoff - Water research, 2003 - Elsevier
The concentrations and removal rate of Triclosan, an antibacterial ingredient in consumer
products, were measured at advanced trickling filter (TF) and activated sludge (AS) …

Theoretical and practical considerations when selecting solvents for use in extractables studies of polymeric contact materials in single-use systems applied in the …

…, I Pahl, I Uettwiller, P Priebe, A Hauk - Industrial & Engineering …, 2018 - ACS Publications
Regulatory authorities require the biopharmaceutical industry to demonstrate that extractables
that may migrate from production systems do not alter the safety, efficacy, potency, or …

A field study of triclosan loss rates in river water (Cibolo Creek, TX)

…, D McAvoy, B Schatowitz, J Inauen, M Jacob, A Hauk… - Chemosphere, 2004 - Elsevier
Triclosan (TCS) is an anti-microbial agent used in down-the-drain consumer products.
Following sewage treatment some of the triclosan will enter receiving waters. This study was …

Lack of evidence for microplastic contamination in honey

P Mühlschlegel, A Hauk, U Walter… - Food Additives & …, 2017 - Taylor & Francis
Honey samples from Switzerland were investigated with regard to their microplastic particle
burden. Five representative honey samples of different origin were processed following a …

Using extractables data from single-use components for extrapolation to process equipment-related leachables: The toolbox and justifications

A Hauk, I Pahl, S Dorey, R Menzel - European Journal of Pharmaceutical …, 2021 - Elsevier
Quantitative information on process equipment-related leachables (PERLs) is required for
process qualification and within a safety assessment. Extractables data for single-use …

X‐ray sterilization of biopharmaceutical manufacturing equipment—Extractables profile of a film material and copolyester Tritan™ compared to gamma irradiation

…, S Dorey, T Maier, I Pahl, A Hauk - Biotechnology …, 2022 - Wiley Online Library
The biopharmaceutical industry gains enormous flexibility in production processes by using
sterilized preassembled single‐use devices. Gamma irradiation is an established …

Quantitative characterization of leachables sinks in biopharmaceutical downstream processing

K Paudel, A Hauk, TV Maier, R Menzel - European Journal of …, 2020 - Elsevier
This article demonstrates, on a quantitative level, that leachables — potentially accumulated
during a biopharmaceutical manufacturing process — will be significantly reduced/removed …

[HTML][HTML] Assessing biologic/toxicologic effects of extractables from plastic contact materials for advanced therapy manufacturing using cell painting assay and …

I Pahl, A Pahl, A Hauk, D Budde, S Sievers, L Fruth… - Scientific Reports, 2024 - nature.com
Plastic components are essential in the pharmaceutical industry, encompassing container
closure systems, laboratory handling equipment, and single-use systems. As part of their …