Protein A affinity chromatography is an important step in the purification of monoclonal antibodies
(mAbs) and mAb‐derived biotherapeutics. While the biopharma industry has extensive …

Activated protein C (APC) is a plasma serine protease with antithrombotic and cytoprotective
functions. Based on the hypothesis that specific inhibition of APC’s anticoagulant but not its …

Protein synthesis in the ribosome's large subunit occurs within an active site comprised
exclusively of RNA. Mutational studies of rRNA active site residues could provide valuable …

In order to create a heme environment that permits biomimicry of heme-containing peroxidases,
a number of new hemin–peptide complexes—hemin-2(18)-glycyl-l-histidine methyl ester …

Companies have adapted high‐throughput techniques for process development to different
levels. Some companies are beginning to incorporate high‐throughput process …

Chromatography resins used for purifying biopharmaceuticals are generally dedicated to a
single product. In good manufacturing practice (GMP) facilities that manufacture a limited …

… Min Lin*, PhD, is a staff development scientist, Ashley Hesslein, PhD, is a senior staff
development scientist, and Jens H. Vogel, PhD, is director of isolation and purification, all at Global …

In clinical monoclonal antibody (mAb) manufacturing, capture on protein A chromatography
resin gives excellent recovery and purity. However, because clinical batch sizes are small, …

Chromatography resins used for purifying biopharmaceuticals are typically dedicated to a
single product. For GMP facilities that make a limited amount of any particular product, this can …

… Associate Director, Sanofi-Genzyme Ashley Hesslein Associate Director, Bayer Norbert
Schuelke, Ph. D. Director, Takeda Pharmaceuticals Hendri Tjandra Staff Scientist, Bayer …