User profiles for Atanas Koulov

Atanas Koulov

CLEAR SOLUTIONS LABORATORIES
Verified email at clearsolutions-labs.com
Cited by 6244

[HTML][HTML] Functional amyloid formation within mammalian tissue

DM Fowler, AV Koulov, C Alory-Jost, MS Marks… - PLoS …, 2006 - journals.plos.org
Amyloid is a generally insoluble, fibrous cross-β sheet protein aggregate. The process of
amyloidogenesis is associated with a variety of neurodegenerative diseases including …

Functional amyloid–from bacteria to humans

DM Fowler, AV Koulov, WE Balch, JW Kelly - Trends in biochemical …, 2007 - cell.com
Amyloid – a fibrillar, cross β-sheet quaternary structure – was first discovered in the context
of human disease and tissue damage, and was thought to always be detrimental to the host. …

[HTML][HTML] Hsp90 cochaperone Aha1 downregulation rescues misfolding of CFTR in cystic fibrosis

X Wang, J Venable, P LaPointe, DM Hutt, AV Koulov… - Cell, 2006 - cell.com
The pathways that distinguish transport of folded and misfolded cargo through the exocytic (secretory)
pathway of eukaryotic cells remain unknown. Using proteomics to assess global …

[HTML][HTML] Semen-derived amyloid fibrils drastically enhance HIV infection

…, PC Sánchez, DM Fowler, A Koulov… - Cell, 2007 - cell.com
Sexual intercourse is the major route of HIV transmission. To identify endogenous factors
that affect the efficiency of sexual viral transmission, we screened a complex peptide/protein …

Biological and structural basis for Aha1 regulation of Hsp90 ATPase activity in maintaining proteostasis in the human disease cystic fibrosis

AV Koulov, P LaPointe, B Lu, A Razvi… - Molecular biology of …, 2010 - Am Soc Cell Biol
The activator of Hsp90 ATPase 1, Aha1, has been shown to participate in the Hsp90 chaperone
cycle by stimulating the low intrinsic ATPase activity of Hsp90. To elucidate the structural …

[PDF][PDF] Chloride transport across vesicle and cell membranes by steroid-based receptors

AV Koulov, TN Lambert, R Shukla, M Jain… - Angewandte Chemie …, 2003 - nd.edu
It is well-established that molecules which transport cations across cell membranes (cationophores)
can have potent biological effects.[1] Anion flux is also important to the cell and, …

[HTML][HTML] Aggregation of Human Recombinant Monoclonal Antibodies Influences the Capacity of Dendritic Cells to Stimulate Adaptive T-Cell Responses In Vitro

…, MC Djidja, A Baban, S Spindeldreher, AV Koulov… - PLoS …, 2014 - journals.plos.org
Subvisible proteinaceous particles which are present in all therapeutic protein formulations
are in the focus of intense discussions between health authorities, academics and …

Subcutaneous injection volume of biopharmaceuticals—pushing the boundaries

R Mathaes, A Koulov, S Joerg, HC Mahler - Journal of pharmaceutical …, 2016 - Elsevier
Administration into the subcutaneous (SC) tissue is a typical route of delivery for therapeutic
proteins, especially for frequent treatments, long-term regimens, or self-administration. It is …

The immunogenicity of antibody aggregates in a novel transgenic mouse model

…, S Schlicht, M Ebeling, A Kiialainen, A Koulov… - Pharmaceutical …, 2015 - Springer
Purpose Protein aggregates have been discussed as a potential risk factor related to
immunogenicity. Here we developed a novel human IgG transgenic (tg) mouse system expressing …

Discrimination between silicone oil droplets and protein aggregates in biopharmaceuticals: a novel multiparametric image filter for sub-visible particles in microflow …

…, K Egodage, M Bluemel, M Jeschke, AV Koulov - Pharmaceutical …, 2012 - Springer
Purpose Accurate monitoring of the sub-visible particle load in protein biopharmaceuticals
is increasingly important to drug development. Manufacturers are expected to characterize …