Freeze drying

AI Liapis, R Bruttini - Handbook of industrial drying, 2020 - taylorfrancis.com
… Litchfield and Liapis (12) found that optimal policies with respect to pressure could be …
pressure policy devel oped by Liapis and Litchfield (9) and Litchfield and Liapis (12). Since the …

Modeling of the primary and secondary drying stages of the freeze drying of pharmaceutical products in vials: Numerical results obtained from the solution of a …

P Sheehan, AI Liapis - Biotechnology and Bioengineering, 1998 - Wiley Online Library
A rigorous unsteady state and spatially multidimensional model is presented and solved to
describe the dynamic behavior of the primary and secondary drying stages of the …

An analysis of the lyophilization process using a sorption‐sublimation model and various operational policies

MJ Millman, AI Liapis, JM Marchello - AIChE Journal, 1985 - Wiley Online Library
The freeze‐drying process is studied under various operational policies through the use of
a sorption‐sublimation model. The operational policy that provides the shortest drying times …

Adsorbents and columns in analytical high‐performance liquid chromatography: A perspective with regard to development and understanding

KK Unger, AI Liapis - Journal of separation science, 2012 - Wiley Online Library
A brief historical survey is presented on the evaluation of silica adsorbents in analytical
HPLC . The theory of analytical HPLC is mostly still being based on the height equivalent to a …

An adsorption-sublimation model for a freeze dryer

RJ Litchfield, AI Liapis - Chemical Engineering Science, 1979 - Elsevier
A model has been constructed using material and energy balances in the dried and frozen
regions of a material undergoing freeze drying. Both sublimatio and adsorption are …

Optimal control of a freeze dryer—I Theoretical development and quasi steady state analysis

AI Liapis, RJ Litchfield - Chemical Engineering Science, 1979 - Elsevier
A mathematical model which describes the nonsteady state heat and mass transfer operations
during the freeze drying process is presented. With the use of this model the problem of …

Freeze-drying of pharmaceuticals in vials on trays: effects of drying chamber wall temperature and tray side on lyophilization performance

KH Gan, R Bruttini, OK Crosser, AI Liapis - International Journal of Heat and …, 2005 - Elsevier
The effects of tray side and drying chamber wall temperature on the performance of freeze-drying
of pharmaceuticals in vials arranged in clusters of hexagonal arrays on trays are …

Theory of perfusion chromatography

AI Liapis, MA McCoy - Journal of Chromatography A, 1992 - Elsevier
A mathematical model of perfusion chromatography was constructed for column systems. This
model could describe the dynamic behavior of single- and multi-component adsorption in …

The coupling of the electrostatic potential with the transport and adsorption mechanisms in ion‐exchange chromatography systems: Theory and experiments

AI Liapis, BA Grimes - Journal of separation science, 2005 - Wiley Online Library
The coupling of the constitutive expression for the electrostatic potential as specified
through Poisson's equation together with the constitutive equations for the mechanisms of …

Determination of the pore connectivity and pore size distribution and pore spatial distribution of porous chromatographic particles from nitrogen sorption …

JJ Meyers, S Nahar, DK Ludlow, AI Liapis - Journal of Chromatography A, 2001 - Elsevier
The pore connectivity, pore size distribution and pore spatial distribution of the porous
structure of native and silanized silica particles were determined by matching the experimental …