The FDA's assessment of follow-on protein products: a historical perspective

…, B Cherney, T Crescenzi, B Fraser… - Nature Reviews Drug …, 2007 - nature.com
… for hepatitis B, in which it was demonstrated that Heptavax B induced … B virus. Recombivax
HB, the first recombinant hepatitis B vaccine, was developed as an alternative to Heptavax B

Overlooking subvisible particles in therapeutic protein products: gaps that may compromise product quality

…, PG Swann, A Rosenberg, B Cherney - Journal of …, 2009 - jpharmsci.org
Therapeutic protein products provide unique and effective treatments for numerous human
diseases and medical conditions. In many cases, these treatments are used chronically to …

Vasostatin, a calreticulin fragment, inhibits angiogenesis and suppresses tumor growth

SE Pike, L Yao, KD Jones, B Cherney… - The Journal of …, 1998 - rupress.org
An endothelial cell inhibitor was purified from supernatant of an Epstein-Barr virus–immortalized
cell line and identified as fragments of calreticulin. The purified recombinant NH 2 -…

The high impact of education abroad: College students' engagement in international experiences and the development of intercultural competencies

M Stebleton, K Soria, B Cherney - 2013 - conservancy.umn.edu
This multi-institutional study attempts to discover whether different international activities in
which students participate yield different outcomes for the development of students’ global …

Interferon-inducible protein-10 identified as a mediator of tumor necrosis in vivo

C Sgadari, AL Angiolillo, BW Cherney… - Proceedings of the …, 1996 - National Acad Sciences
… The Epstein–Barr virus-immortalized VDS-O cell line was obtained by spontaneous outgrowth
of peripheral blood B cells from an Epstein–Barr virus-seropositive normal individual (19). …

Calreticulin and calreticulin fragments are endothelial cell inhibitors that suppress tumor growth

…, L Yao, J Setsuda, KD Jones, B Cherney… - Blood, The Journal …, 1999 - ashpublications.org
Several angiogenesis inhibitors are fragments of larger proteins that are themselves not
active as angiogenesis inhibitors. Vasostatin, the N-terminal domain of calreticulin inclusive of …

Comparison of home antigen testing with RT-PCR and viral culture during the course of SARS-CoV-2 infection

…, RD Anderson, AK Chakrabarti, B Cherney… - JAMA internal …, 2022 - jamanetwork.com
… Although this investigation occurred before the emergence of the Omicron (B.1.1.529) lineage,
a recent study with 731 participants found that antigen tests continue to perform well with …

cDNA sequence, protein structure, and chromosomal location of the human gene for poly (ADP-ribose) polymerase.

BW Cherney, OW McBride, DF Chen… - Proceedings of the …, 1987 - National Acad Sciences
Recently we described a full-length cDNA for the human nuclear enzyme poly(ADP-ribose)
polymerase. Here, we report the chromosomal localization and partial map of the human …

The role of insertions/deletions in the evolution of the intergenic region betweenpsbA andtrnH in the chloroplast genome

J Aldrich, BW Cherney, E Merlin - Current genetics, 1988 - Springer
… two genes in alfalfa and petunia because a) it lies close to the end of the large single copy
region, which is known to be a hot spot for length mutations (reviewed in Palmer 1985a), b) …

Managing uncertainty: a perspective on risk pertaining to product quality attributes as they bear on immunogenicity of therapeutic proteins

AS Rosenberg, D Verthelyi, BW Cherney - Journal of pharmaceutical …, 2012 - Elsevier
The critical question addressed in this paper regards how industry and regulatory agencies
should manage the risk of adverse events to patients posed by product quality attributes for …