Advances in clone selection using high‐throughput bioreactors

B Kondragunta, JL Drew, KA Brorson… - Biotechnology …, 2010 - Wiley Online Library
Effective clone selection is a crucial step toward developing a robust mammalian cell culture
production platform. Currently, clone selection is done by culturing cells in well plates and …

Genomic analysis of a hybridoma batch cell culture metabolic status in a standard laboratory 5 L bioreactor

B Kondragunta, J Han, BH Joshi… - Biotechnology …, 2012 - Wiley Online Library
Currently, there is a gap in the knowledge of the culture responses to controlled bioreactor
environment during the course of batch cell culture from early exponential phase to stationary‐…

Bioreactor environment‐sensitive sentinel genes as novel metrics for cell culture scale‐down comparability

B Kondragunta, BH Joshi, J Han… - Biotechnology …, 2012 - Wiley Online Library
Scale‐down of bioreactors is currently done based on matching one or more measurable
parameters such as k L a and P/V, which could result in insufficient process comparability. …

[BOOK][B] Bioprocess convergence using sentinel genes for process parameter tuning

B Kondragunta - 2011 - search.proquest.com
In vitro cell culture is a vital part of therapeutic biomolecule, cell therapy and vaccine
production. In order to assure product identity, safety, potency and efficacy, controlled …

Studies of protein oxidation as a product quality attribute on a scale-down model for cell culture process development

ND Lee, B Kondragunta, S Uplekar… - PDA Journal of …, 2015 - journal.pda.org
Of importance to the biological properties of proteins produced in cell culture systems are
the complex post-translational modifications that are affected by variations in process …

[CITATION][C] Analytical technology used in the latest development of gene therapy candidates

…, K O'Brian, B Howie, C Zhang, B Kondragunta… - Cell and Gene Therapy …, 2019 - cir.nii.ac.jp
Analytical Technology Used in the Latest Development of Gene Therapy Candidates | CiNii
Research CiNii 国立情報学研究所 学術情報ナビゲータ[サイニィ] 詳細へ移動 検索フォームへ移動 …

A Rare Decade Where Magic Could Happen

B Kondragunta - PDA Journal of Pharmaceutical Science and …, 2016 - journal.pda.org
Rare Disease Day takes place every year on the last day of February. This day was established
in Europe in 2008, and is now observed in more than 80 nations. To put it in perspective, …

Improving upstream bioprocessing by enabling process scouting devices with low cost, disposable oxygen and pH sensors

JR Vallejos-Membreno - 2011 - search.proquest.com
… I would also like to thank my Lab mates Bhargavi Kondragunta and Shaunak … to
Bhargavi for training me in aseptic mammalian cell culture techniques. Beyond the …

Optical sensor enabled rocking T‐flasks as novel upstream bioprocessing tools

JR Vallejos, M Micheletti, KA Brorson… - Biotechnology and …, 2012 - Wiley Online Library
… Authors thank Bhargavi Kondragunta and Shaunak Uplekar for their assistance with wave
bioreactor cell culture experiments as well as insightful discussions with Erik Read. Authors …

[CITATION][C] Evaluation of scale-down to novel stirred high-throughput mini-bioreactors using genomic profiling of a hybridoma cell-line

B Kondragunta, BH Joshi… - ABSTRACTS …, 2011 - … CHEMICAL SOC 1155 16TH ST, NW …