Human immunodeficiency virus (HIV) virion infectivity factor (Vif) causes the proteasome-mediated
destruction of human antiviral protein APOBEC3G by tethering it to a cellular E3 …

All canonical transfer RNAs (tRNAs) have a uridine at position 8, involved in maintaining
tRNA tertiary structure. However, the hyperthermophilic archaeon Methanopyrus kandleri …

The transmembrane (TM) domain of the major histocompatibility complex (MHC) class II-associated
invariant chain (Ii) has long been implicated in both correct folding and function of …

This study investigates the mechanism of protein particle formation during ultrafiltration/diafiltration
(UF/DF), finding that agitation drives particle formation by promoting protein-interface …

The human immunodeficiency virus type 1 (HIV-1) protein Vif recruits the host E3 ubiquitin
ligase, composed of cullin 5 (Cul5), Rbx2, Elongin B, and Elongin C (EloBC), to …

ABCG2 is an ATP-binding cassette half-transporter important in normal tissue protection,
drug distribution, and excretion. ABCG2 requires homodimerization for function, though the …

No‐salt flowthrough hydrophobic interaction chromatography (HIC) has been shown to
effectively remove process and product‐related impurities from bioprocess streams. In this …

Patient-controlled analgesia has become standard practice after major abdominal operations.
The benefits of patient-controlled analgesia have been well documented. However, its …

Virus filtration has been demonstrated to be an effective and robust dedicated viral clearance
step that is used in biopharmaceutical manufacturing processes. Here we present virus …

The BioPhorum Development Group Viral Clearance Workstream performed a collaborative
retrospective analysis to evaluate packed bed chromatographic resin performance after …