It has recently been demonstrated that in vivo administration of murine interleukin 12 (IL-12)
to mice results in augmentation of cytotoxic natural killer (NK)/lymphocyte-activated killer cell …

This paper presents an overview of large-scale downstream processing of monoclonal
antibodies and Fc fusion proteins (mAbs). This therapeutic modality has become increasingly …

Hepatic steatosis, the accumulation of lipids in the liver, is widely believed to result in insulin
resistance. To test the causal relationship between hepatic steatosis and insulin resistance, …

Antibiotics are precious resources in the fight to combat bacterial infections caused by
pathogenic organisms. Vancomycin is one of the antibiotics of last resort in the treatment of life‐…

Nonribosomal peptide synthetases are large enzyme complexes that synthesize a variety of
peptide natural products through a thiotemplated mechanism. Assembly of the peptides …

2 Is a heterodlmerlc cytoklne that has been shown to enhance natural killer (NK) and cytotoxic
T lymphocyte (CTL) responses, and to induce IFN-γ production in vitro. In this study, we …

The protein PCSK9 (proprotein convertase subtilisin/kexin type 9) is a key regulator of low‐density
lipoprotein receptor (LDLR) levels and cardiovascular health. We have determined …

In an attempt to understand the applicability of various animal models to dyslipidemia in
humans and to identify improved preclinical models for target discovery and validation for …

Objective— To examine the effects of treatments with niacin or anacetrapib (an inhibitor of
cholesteryl ester transfer protein) on the ability of high-density lipoprotein (HDL) to promote …

Diet-induced obesity (DIO) leads to inflammatory activation of macrophages in white adipose
tissue (WAT) and subsequently to insulin resistance. PPARγ agonists are antidiabetic …