[HTML][HTML] Low-dose nitric oxide as targeted anti-biofilm adjunctive therapy to treat chronic Pseudomonas aeruginosa infection in cystic fibrosis

…, K Cathie, L Hall-Stoodley, V Cornelius, C Duignan… - Molecular Therapy, 2017 - cell.com
Despite aggressive antibiotic therapy, bronchopulmonary colonization by Pseudomonas
aeruginosa causes persistent morbidity and mortality in cystic fibrosis (CF). Chronic P. …

Conservation genetics of Ireland's sole population of the River water crowfoot (Ranunculus fluitans Lam.)

CR Bradley, C Duignan, SJ Preston, J Provan - Aquatic botany, 2013 - Elsevier
Populations of many freshwater species are becoming increasingly threatened as a result of
a wide range of anthropogenically mediated factors. In the present study, we wanted to …

Increased rates of genomic mutation in a biofilm co-culture model of Pseudomonas aeruginosa and Staphylococcus aureus

…, RP Howlin, O Soren, BT McDonagh, CM Duignan… - BioRxiv, 2018 - biorxiv.org
Biofilms are major contributors to disease chronicity and are typically multi-species in nature.
Pseudomonas aeruginosa and Staphylococcus aureus are leading causes of morbidity …

A Systematic Approach for the Evaluation, Validation, and Implementation of Automated Colony Counting Systems

S Deutschmann, B Carpenter, C Duignan… - PDA Journal of …, 2022 - journal.pda.org
For several years, automated colony counting systems have been available with varying
degrees of automation. Ever more sophisticated instruments are now increasingly used in …

[PDF][PDF] An exploration of power within the context of strategic collaborative working towards outcomes for children and young people

C Duignan - 2023 - aran.library.nuigalway.ie
Approaches which support strategic collaboration across a range of service provision contexts
for children, young people and families have grown exponentially in recent decades. Yet …

Influence of low-dose nitric oxide on mono-and mixed-species biofilms formed by bacteria isolated from cystic fibrosis patients

CM Duignan - 2017 - eprints.soton.ac.uk
Cystic fibrosis (CF) is an autosomal recessive disorder. One of the characteristic hallmarks
of the disease is infection of the lung. Over the life time of a CF patient, a number of …

[CITATION][C] Low dose nitric oxide as adjunctive therapy to reduce antimicrobial tolerance of Pseudomonas aeruginosa biofilms in the treatment of patients with cystic …

…, V Cornelius, T Daniels, C Duignan… - B38. Update in adult …, 2014 - atsjournals.org
Rationale: state. In cystic fibrosis (CF), chronic(PA) infection cannot be eradicated with
conventional antibiotics, leading to Pseudomonas aeruginosa increased hospitalisation, …

Molecular mechanism of nitric oxide-mediated regulation of intracellular cyclic-di-GMP in Pseudomonas aeruginosa biofilms

Y Cai - 2018 - eprints.soton.ac.uk
Caroline Duignan for their detailed guidance and help in the CL2 lab, and to Dr. Curtis
Phippen for his hand -by- hand help and guidance on molecular work as well as the fruitful …

Genetic and phenotypic diversification within biofilms formed by clinically relevant strains of Streptococcus pneumoniae

N Churton - 2014 - eprints.soton.ac.uk
Streptococcus pneumoniae is a commensal human pathogen and the causative agent of
invasive pneumococcal disease. Carriage of the pneumococcus in the nasopharynx of humans …

Call for Papers in the Area of Cardiovascular Regenerative Medicine

S Ylӓ-Herttuala - Molecular Therapy, 2017 - cell.com
Last year, Molecular Therapy initiated a special issue program designed to highlight cutting
edge research topics of strong interest to our readership. The first such special issue, on the …