Therapeutic proteins produced using recombinant DNA technologies are generally complex,
heterogeneous, and subject to a variety of enzymatic or chemical modifications during …

A reversed-phase high-performance liquid chromatography (HPLC) separation approach
has been combined with ion mobility/time-of-flight (TOF) mass spectrometry in order to …

Ion mobility measurements and molecular modeling techniques have been used to survey
the gas-phase structures of a series of alanine-rich peptides. The peptides, examined as [M + …

Recent improvements in ion mobility/time-of-flight mass spectrometry techniques have
made it possible to incorporate nano-flow liquid chromatography and collision induced …

Combinatorial peptide synthesis in combination with affinity selection and high-resolution ion
mobility/time-of-flight mass spectrometry (IM/TOFMS) analysis has been used to investigate …

High-performance liquid chromatography (HPLC) has been combined with high-resolution
ion mobility separations and time-of-flight mass spectrometry (MS) for the analysis of complex …

This workshop report summarizes the presentations, the breakout session outcomes, and
the speaker panel discussions from the PDA Biosimilars Workshop held September 27–28, …

Ion mobility/time-of-flight techniques have been used to examine the onset of aggregation in
model systems of Gly-Xxx (where Xxxx = Ala, Asn, Asp, Gln, Glu, His, Leu, Ser, Thr, and Trp) …

The development of a multidimensional approach involving high-performance liquid
chromatography (LC), ion mobility spectrometry (IMS) and tandem mass spectrometry is described …

Regulatory approval of biosimilar products requires demonstration of analytical similarity of
functional and structural attributes between the proposed biosimilar product and on-market …