Intraneuronal accumulation of ubiquitin conjugates in inclusion bodies and neurofibrillary
tangles is a pathological feature of neurodegenerative disorders such as Alzheimer's disease …

Purpose: To describe the Food and Drug Administration review and marketing approval
considerations for panitumumab (Vectibix) for the third-line treatment of patients with epidermal …

Learning Objectives Compare survival outcomes among patients with SCCHN treated with
a platinum/5 ‐FU regimen with and without cetuximab. Compare adverse event profiles …

Strikingly increased expression of notch‐1 has been demonstrated in several human
malignancies and pre‐neoplastic lesions. However, the functional consequences of notch‐1 …

An increasing number of monoclonal antibodies for cancer diagnosis and treatment are in
clinical use and in the development pipeline, with more expected as new molecular targets …

Passage of the Biologics Price Competition and Innovation Act of 2009 created an
abbreviated licensure pathway for biosimilar products. The FDA approved ABP215 (MVASI, …

The goldfish visual pathway displays a remarkable capacity for continued development and
plasticity. The intermediate filament proteins of this pathway do not match the intermediate …

The goldfish visual pathway displays a remarkable capacity for continued development and
plasticity. The intermediate filament proteins in this pathway are unexpected and atypical, …

Keratins are the predominant intermediate filament proteins in the nonneuronal cells of the
goldfish optic nerve. At least three different keratin pairs are expressed in this tissue, …

The adult goldfish retina and optic nerve display continuous growth, plasticity, and the
capacity to regenerate throughout the animal's life. The intermediate filament proteins in this …