Iron maldistribution has been implicated in multiple diseases, including the anemia of
inflammation (AI), atherosclerosis, diabetes, and neurodegenerative disorders. Iron metabolism is …

Ferroportin is the primary means of cellular iron efflux and a key component of iron metabolism.
Hepcidin regulates Fpn activity by inducing its internalization and degradation. The …

Despite the prevalence of KRAS mutations in human cancers, there remain no targeted
therapies for treatment. The serine–threonine kinase STK33 has been proposed to be required …

Recombinant adeno-associated virus (rAAV) vectors are a leading gene delivery platform,
but vector manufacturing remains a challenge. New methods are needed to increase rAAV …

Epidermal growth factor receptor (EGFR) kinase domain mutations cause hyperresponsiveness
to ligand and hypersensitivity to small-molecule tyrosine kinase inhibitors. However, little …

The transient receptor potential ankyrin 1 (TRPA1) channel has been implicated in different
pathophysiologies that include asthma, cough, itch, and inflammatory pain. Agonists of …

The family of signal transducers and activators of transcription (STATs) consists of seven
transcription factors that respond to a variety of cytokines, hormones, and growth factors. STATs …

Activation of the inducible costimulator (ICOS) signaling pathway in T cells is difficult to assess
with bioassays, because most T cell lines do not constitutively express ICOS. Additionally, …

Lentiviral vectors (LVs) are frequently used to engineer cell lines for preclinical research
purposes including assay development and target validation. Development of production cell …

Background: A key obstacle in the treatment of cancer is resistance to targeted therapy.
Recent reports suggest that growth factors and their receptors may play a role in mediating this …