Selectin-mediated adhesion of tumor cells to platelets, leukocytes, and endothelial cells may
regulate their hematogenous dissemination in the microvasculature. We recently identified …

Selectins and fibrin(ogen) play key roles in the hematogenous dissemination of tumor cells,
and especially of colon carcinomas. However, the fibrin(ogen) receptor(s) on colon …

Based on an optimized electroporation protocol, we designed a rapid, milliliter‐scale diagnostic
transient production assay to identify limitations in the ability of Chinese hamster ovary (…

Introduction Polyneuropathy signs (Neuropathy Impairment Score, NIS), neurophysiologic
tests (m+7 Ionis ), disability, and health scores were assessed in baseline evaluations of 100 …

Highlights • The high-titer process can lead to inefficient protein secretion and aggregation.
• Genetic engineering has shown promise to tackle bottlenecks in secretion pathways. • …

Blood vessel development is in part regulated by pericytes/presumptive vascular smooth
muscle cells (PC/pvSMCs). Here, we demonstrate that interactions between PC/pvSMCs and …

CD44 and fibrin(ogen) play critical roles in the hematogenous dissemination of tumor cells,
including colon carcinomas. We recently reported that CD44 is the primary fibrin, but not …

For commercial protein therapeutics, Chinese hamster ovary (CHO) cells have an established
history of safety, proven capability to express a wide range of therapeutic proteins and …

CD44 is a multifunctional glycoprotein that binds to hyaluronan and fibrin(ogen). Alternative
splicing is responsible for the generation of numerous different isoforms, the smallest of …

Corticosteroids synergize with the thyroid hormone (TH) at late metamorphic stages and
might have a role in the hormonal regulation of amphibian metamorphosis. This role could be …