The direct mechanism by which the serine/threonine kinase Akt (also known as protein kinase
B (PKB)) regulates cell growth is unknown. Here, we report that Drosophila melanogaster …

In Drosophila, ∼50 classes of olfactory receptor neurons (ORNs) send axons to 50 corresponding
glomeruli in the antennal lobe. Uniglomerular projection neurons (PNs) relay olfactory …

We describe a new repressible binary expression system based on the regulatory genes
from the Neurospora qa gene cluster. This "Q system" offers attractive features for transgene …

Tuberous sclerosis complex is a dominant disorder that leads to the development of benign
tumors in multiple organs. We have isolated a mutation in the Drosophila homolog of TSC1 (…

Mutations in the tumor suppressor gene PTEN (MMAC1/TEP1) are associated with a large
number of human cancers and several autosomal-dominant disorders. Mice mutant for PTEN …

Genetically encoded effectors are important tools for probing cellular function in living animals,
but improved methods for directing their expression to specific cell types are required. …

Tissue-specific gene expression using the upstream activating sequence (UAS)–GAL4
binary system has facilitated genetic dissection of many biological processes in Drosophila …

The Q system is a repressible binary expression system for transgenic manipulations in
living organisms. Through protein engineering and in vivo functional tests, we report here …

Various insect species serve as valuable model systems for investigating the cellular and
molecular mechanisms by which a brain controls sophisticated behaviors. In particular, the …

Mosquitoes are vectors for multiple infectious human diseases and use a variety of sensory
cues (olfactory, temperature, humidity and visual) to locate a human host. A comprehensive …