Human melanoma cells transplanted into zebrafish proliferate, migrate, produce melanin, form masses and stimulate angiogenesis in zebrafish
M Haldi, C Ton, WL Seng, P McGrath - Angiogenesis, 2006 - Springer
In this research, we optimized parameters for xenotransplanting WM-266-4, a metastatic
melanoma cell line, including zebrafish site and stage for transplantation, number of cells, …
melanoma cell line, including zebrafish site and stage for transplantation, number of cells, …
Gene expression profile of zebrafish exposed to hypoxia during development
C Ton, D Stamatiou, CC Liew - Physiological Genomics, 2003 - journals.physiology.org
Understanding how vertebrates respond to hypoxia can have important clinical implications.
Fish have evolved the ability to survive long exposure to low oxygen levels. However, little …
Fish have evolved the ability to survive long exposure to low oxygen levels. However, little …
Zebrafish as a model for developmental neurotoxicity testing
C Ton, Y Lin, C Willett - Birth Defects Research Part A: Clinical …, 2006 - Wiley Online Library
BACKGROUND: To establish zebrafish as a developmental toxicity model, we used 7 well‐characterized
compounds to examine several parameters of neurotoxicity during …
compounds to examine several parameters of neurotoxicity during …
The use of zebrafish for assessing ototoxic and otoprotective agents
C Ton, C Parng - Hearing research, 2005 - Elsevier
Zebrafish and other fish exhibit hair cells in the lateral-line neuromasts which are structurally
and functionally similar to mammalian inner ear hair cells. To facilitate drug screening for …
and functionally similar to mammalian inner ear hair cells. To facilitate drug screening for …
Neurotoxicity assessment using zebrafish
C Parng, NM Roy, C Ton, Y Lin, P McGrath - Journal of pharmacological …, 2007 - Elsevier
Introduction: Transparency is a unique attribute of zebrafish that permits direct assessment
of drug effects on the nervous system using whole mount antibody immunostaining and …
of drug effects on the nervous system using whole mount antibody immunostaining and …
Construction of a zebrafish cDNA microarray: gene expression profiling of the zebrafish during development
C Ton, D Stamatiou, VJ Dzau, CC Liew - Biochemical and Biophysical …, 2002 - Elsevier
Vertebrate embryogenesis is a complex process controlled by a transcriptional hierarchy
that coordinates the action of thousands of genes. To identify and analyze the expression …
that coordinates the action of thousands of genes. To identify and analyze the expression …
[HTML][HTML] Development and scale-up of rVSV-SARS-CoV-2 vaccine process using single use bioreactor
C Ton, V Stabile, E Carey, A Maraikar, T Whitmer… - Biotechnology …, 2023 - Elsevier
The outbreak of the novel severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)
that causes the Coronavirus Disease 2019 (COVID-19) has spread through the globe at an …
that causes the Coronavirus Disease 2019 (COVID-19) has spread through the globe at an …
A zebrafish assay for identifying neuroprotectants in vivo
C Parng, C Ton, YX Lin, NM Roy, P McGrath - Neurotoxicology and …, 2006 - Elsevier
In this study, we developed an in vivo method to determine drug effects on oxidation-induced
apoptosis in the zebrafish brain caused by treatment with l-hydroxyglutaric acid (LGA). We …
apoptosis in the zebrafish brain caused by treatment with l-hydroxyglutaric acid (LGA). We …
Zebrafish apoptosis assays for drug discovery
C Parng, N Anderson, C Ton, P McGrath - Methods in cell biology, 2004 - Elsevier
Publisher Summary This chapter discusses Zebrafish apoptish assays for drug discovery. It
describes the zebrafish apoptosis gene, caspase substrate recognition, and in situ apoptosis …
describes the zebrafish apoptosis gene, caspase substrate recognition, and in situ apoptosis …
High performance DNA sequencing, and the detection of mutations and polymorphisms, on the Clipper sequencer
…, D Rushlow, E Steinbach, C Ton… - …, 1999 - Wiley Online Library
The Visible Genetics Clipper sequencer is a new platform for automated DNA sequencing
which employs disposable MicroCel cassettes and 50 μm thick polyacrylamide gels. Two DNA …
which employs disposable MicroCel cassettes and 50 μm thick polyacrylamide gels. Two DNA …