Identification of pharmaceutical impurities

F Qiu, DL Norwood - Journal of liquid chromatography & related …, 2007 - Taylor & Francis
Norwood and QiuCitation166 studied the application of chloride attachment APCI LC‐MS
in identification of impurities in a nitroglycerin ointment. Nitroglycerin and the two …

Tandem mass spectrometry: a new method for acylcarnitine profiling with potential for neonatal screening for inborn errors of metabolism

DS Millington, N Kodo, DL Norwood… - Journal of inherited …, 1990 - Springer
Conclusion A method for analysis of acylcarnitines in blood at physiological concentrations
has been developed. Preliminary results from umbilical cord blood and neonatal blood …

Best practices for extractables and leachables in orally inhaled and nasal drug products: an overview of the PQRI recommendations

DL Norwood, D Paskiet, M Ruberto, T Feinberg… - Pharmaceutical …, 2008 - Springer
The Product Quality Research Institute Leachables and Extractables Working Group includes
pharmaceutical development scientists representing industry, government, and academia. …

The Product Quality Research Institute (PQRI) leachables and extractables working group initiatives for parenteral and ophthalmic drug product (PODP)

…, D Jenke, D Ball, C Houston, DL Norwood… - PDA Journal of …, 2013 - journal.pda.org
The Product Quality Research Institute (PQRI) is a non-profit consortium of organizations
working together to generate and share timely, relevant, and impactful information that …

Identity and yields of major halogenated products of aquatic fulvic acid chlorination

RF Christman, DL Norwood, DS Millington… - … science & technology, 1983 - ACS Publications
Chlorination of fulvic acid isolatedfrom a natural surface water produces a variety of Cx to
C4 aliphatic acids in addition to chloroform. Yields of the four principal reaction products, …

Reactions of chlorine with selected aromatic models of aquatic humic material

DL Norwood, JD Johnson, RF Christman… - … science & technology, 1980 - ACS Publications
A series of compounds designed to model the monomeric components of aquatic humic
material was reacted with aqueous chlorine at pH 7. Chloroform production and chlorine …

Application of fast atom bombardment with tandem mass spectrometry and liquid chromatography/mass spectrometry to the analysis of acylcarnitines in human urine …

DS Millington, DL Norwood, N Kodo, CR Roe… - Analytical …, 1989 - Elsevier
Using a precursor-ion scan function on a triple quadrupole mass spectrometer, acylcarnitines
were detected in the target matrices at or below concentrations of 1 nmol per gram by fast …

Structural characterization of aquatic humic material. 2. Phenolic content and its relationship to chlorination mechanism in an isolated aquatic fulvic acid

DL Norwood, RF Christman… - Environmental science & …, 1987 - ACS Publications
The complementary techniques of solid-state 13C nuclear magnetic resonance spectroscopy
and chemical degradation were utilized to examine the lignin/phenolic substructure of an …

Extractables characterization for five materials of construction representative of packaging systems used for parenteral and ophthalmic drug products

…, A Shaw, K Nicholas, DL Norwood… - PDA Journal of …, 2013 - journal.pda.org
Polymeric and elastomeric materials are commonly encountered in medical devices and
packaging systems used to manufacture, store, deliver, and/or administer drug products. …

Development of safety qualification thresholds and their use in orally inhaled and nasal drug product evaluation

…, RO McClellan, T McGovern, DL Norwood… - Toxicological …, 2007 - academic.oup.com
Safety thresholds for chemical impurities and leachables in consumer products such as
foods and drugs have helped to ensure public health while establishing scientifically sound …