Adoptive Cell Transfer Therapy Following Non-Myeloablative but Lymphodepleting
Chemotherapy for the Treatment of Patients With Refractory Metastatic Melanoma - PMC …

Activation of the Hedgehog (Hh) signalling pathway by sporadic mutations or in familial
conditions such as Gorlin's syndrome is associated with tumorigenesis in skin, the cerebellum …

A novel class of regulators of G protein signaling (RGS) proteins has been identified recently.
Genetic evidence suggests that RGS proteins inhibit G protein–mediated signaling at the …

Background Ipilimumab, a fully human monoclonal antibody that blocks cytotoxic T-lymphocyte
antigen-4, has demonstrated an improvement in overall survival in two phase III trials of …

Purpose: Diarrhea (with or without colitis) is an immune-related adverse event (irAE)
associated with ipilimumab. A randomized, double-blind, placebo-controlled, multicenter, …

Purpose To provide a more precise estimate of long-term survival observed for ipilimumab-treated
patients with advanced melanoma, we performed a pooled analysis of overall survival …

Cancer is increasingly being viewed as a stem cell disease, both in its propagation by a
minority of cells with stem-cell-like properties and in its possible derivation from normal tissue …

Embryonic signalling pathways regulate progenitor cell fates in mammalian epithelial
development and cancer 1 , 2 . Prompted by the requirement for sonic hedgehog (Shh) signalling …

Metastatic cancers adopt certain properties of normal cells in developing or regenerating
organs, such as the ability to proliferate and alter tissue organization. We find here that activity …

Adult cancers may derive from stem or early progenitor cells 1 , 2 . Epigenetic modulation of
gene expression is essential for normal function of these early cells but is highly abnormal in …