The natural flavonoid fisetin (3,3′,4′,7-tetrahydroxyflavone) has shown antitumour activity
but its administration is complicated by its low water solubility. Our aim was to incorporate …

Absolute bioavailability of cefpodoxime proxetil is both limited by its low solubility in aqueous
solution and its intraluminal hydrolysis. The oil-in-water submicron emulsion was proven to …

Three multiple water-in-oil-in-water (W/O/W) nanoemulsions have been designed for potential
inclusion of either lipophilic or hydrophilic drugs using a two-step emulsification process …

Introduction Parenteral nutrition (PN) plays an important role in the nutritional support of
very preterm newborns. It has been suggested that a high proportion of PN orders could be …

Environmental and biological monitoring of platinum containing drugs was implemented in
two French hospital pharmacies using positive air pressure isolators and having similar …

The possible involvement of P-glycoprotein (P-gp) and cytochrome P450 (CYP) 3A4 in
risperidone transport was investigated using in vitro and in vivo models. Firstly, uptake studies …

Purpose Aseptic technique of pharmacy operators was assessed using simulated media-fill
tests challenged with microorganisms. Methods Simulation of the process was done in …

… Brossard and S. Bénazeth … Emmanuel Curis,ab Karine Provost,c Diane Bouvet,c
Ioannis Nicolis,ab Sylvie CrausteMancietde, Denis Brossardde and Simone Bénazethab …

Cefpodoxime proxetil is an orally active, broad spectrum, third generation cephalosporin
ester. This prodrug was previously found to be hydrolyzed in vitro both in rabbit and human …

Platinum compounds constitute a discrete class of DNA-damaging anticancer drug agents,
including cisplatin, carboplatin, and oxaliplatin. The toxicity of such drugs raises the problem …