Monovalent bispecific IgGs cater to a distinct set of mechanisms of action but are difficult to
engineer and manufacture because of complexities associated with correct heavy and light …

Reversible self-association of protein therapeutics, the phenomenon of formation of native
reversible oligomeric species as a result of noncovalent intermolecular interactions, can add …

Immunoglobulin G–like bispecific antibodies with asymmetric architecture are among the
most widely used bispecific antibody formats for diagnostic and therapeutic applications. The …

We have systematically investigated six compendial nonionic detergents as potential
replacements for Triton ×‐100 in bioprocessing applications. Use of compendial raw materials in …

Endotoxins are complex molecules and one of the most challenging impurities requiring
separation in biopharmaceutical protein purification processes. Usually these contaminants are …

The analysis and accurate quantitation of bioconjugations proves challenging in the case of
oligomeric proteins, especially when the size of the molecule or the nature of the conjugate …

Following re-examination of the raw data used for the generation of Figure 7B in the paper “Improving
target cell specificity using a novel monovalent bispecific IgG design” by Mazor et …