Background WHO and Health Action International (HAI) have developed a standardised
method for surveying medicine prices, availability, affordability, and price components in low-…

Because of its requirement for signaling by multiple cytokines, Janus kinase 3 (JAK3) is an
excellent target for clinical immunosuppression. We report the development of a specific, …

Purpose Cabozantinib, a tyrosine kinase inhibitor (TKI) of hepatocyte growth factor receptor (MET),
vascular endothelial growth factor receptor 2, and rearranged during transfection (…

Notch signaling regulates cell fate decisions in a wide variety of adult and embryonic tissues.
Here we show that Notch pathway components and Notch target genes are upregulated in …

Differentiated thyroid carcinomas is associated with an excellent prognosis. The treatment
of choice for differentiated thyroid carcinoma is surgery, followed by radioactive iodine …

Purpose XL184 (cabozantinib) is a potent inhibitor of MET, vascular endothelial growth
factor receptor 2 (VEGFR2), and RET, with robust antiangiogenic, antitumor, and anti-invasive …

Among the various forms of human lung cancer, small cell lung cancer (SCLC) exhibits a
characteristic neuroendocrine (NE) phenotype. Neural and NE differentiation in SCLC depend, …

In Drosophila and in vertebrates, the achaete-scute family of basic helix–loop–helix transcription
factors plays a critical developmental role in neuronal commitment and differentiation 1–…

The role of Notch signaling in tumorigenesis can vary; Notch1 acts as an oncogene in some
neoplasms, and a tumor suppressor in others. Here, we show that different Notch receptors …

The achaete-scute genes encode essential transcription factors in normal Drosophila and
vertebrate nervous system development. Human achaete-scute homolog-1 (hASH1) is …