… E ed with immobilized antibody to 3DO E … The same gene has also been identified and
called E5-1 by EI Rogaev et al. [Nature 376, 775 (1995)]. The A25 and B15 inserts were - 1200 …

Mice homozygous for a single tyrosine mutation in LAT (linker for activation of T cells) exhibited
an early block in T cell maturation but later developed a polyclonal lymphoproliferative …

… (E) Little apoptosis was seen in dPC12 cells after treatment for 2 days with aged Aβ(1–42)
(21… 4E). The ability of Aβ to activate the apoptotic pathway mediated by wild-type PS2 is similar …

Biosimilar development has a well‐documented foundation of product quality and extensive
comparative analytics providing the bulk of the “totality of the evidence” that a proposed …

Sphingosine kinase catalyzes the phosphorylation of sphingosine to form sphingosine 1‐phosphate
(SPP), a novel lipid mediator with both intra‐ and extracellular functions. Based on …

Biologics can be seen as “designer” drugs whose mode of action in a specific disease
mechanism is frequently well understood, making it often possible to predict better efficacy and …

Sphingosine-1-phosphate (S1P) is a bioactive sphingolipid metabolite that has novel dual
actions. S1P is the ligand for a family of G protein-coupled receptors known as S1PRs that …

ALG-3, a truncated mouse homologue of the chromosome 1 familial Alzheimer's disease gene
PS2, rescues T hybridoma 3DO cells from T-cell receptor-induced apoptosis by inhibiting …

The apoptosis-linked gene product, ALG-2, is a member of the family of intracellular Ca 2+ -binding
proteins and a part of the apoptotic machinery controlled by T-cell receptor (TCR), …

Antibody responses to life saving therapeutic protein products, such as enzyme replacement
therapies (ERT) in the setting of lysosomal storage diseases, have nullified product efficacy …