… antioxidant enzymes such as catalase, superoxide dismutase, peroxiredoxins, and glutathione
peroxidase as well as low-molecular-weight compounds such as vitamins C and E and …

A substantial body of evidence supports the conclusion that chronic inflammation can
predispose an individual to cancer, as demonstrated by the association between chronic …

There now exists a bewildering array of biological processes in which free radicals have
been implicated ( 1 ), and we assume that enzymes and structural proteins may be attacked …

… after treatment with the inflammatory oil pristane [E. Shacter, GK Arzadon, and J. Williams, …
We have used the mouse monoclonal immunoglobulin E (IgE) from Sigma (St. Louis, MO, D-…

Human pharmacokinetics data indicate that iv ascorbic acid (ascorbate) in pharmacologic
concentrations could have an unanticipated role in cancer treatment. Our goals here were to …

Ascorbate (ascorbic acid, vitamin C), in pharmacologic concentrations easily achieved in
humans by iv administration, selectively kills some cancer cells but not normal cells. We …

Plasma proteins are exposed to oxidants in a variety of circumstances in vivo, such as during
tissue injury and inflammation. In this report, the relative susceptibility of each of the major …

Rapid phagocytosis of apoptotic cells is thought to limit the development of inflammation and
autoimmune disease. Serum enhances macrophage phagocytosis of apoptotic cells. Here …

… experiments described in this report and by Shacter et al. (15) show that PGE2 synthesis is
likely responsible for most of the elevation of IL-6 found when mice are subjected to a chronic …

Apoptosis and necrosis are two forms of cell death that are induced under different conditions
and that differ in morphological and biochemical features. In this report, we show that, in …