Publisher Summary Enzymes and structural proteins may be attacked whenever free radicals
are generated. As a consequence, oxidative modification of proteins may occur in a variety …

Human pharmacokinetics data indicate that iv ascorbic acid (ascorbate) in pharmacologic
concentrations could have an unanticipated role in cancer treatment. Our goals here were to …

Protein oxidation is defined here as the covalent modification of a protein induced either
directly by reactive oxygen species or indirectly by reaction with secondary by-products of …

A substantial body of evidence supports the conclusion that chronic inflammation can
predispose an individual to cancer, as demonstrated by the association between chronic …

Ascorbate (ascorbic acid, vitamin C), in pharmacologic concentrations easily achieved in
humans by iv administration, selectively kills some cancer cells but not normal cells. We …

Plasma proteins are exposed to oxidants in a variety of circumstances in vivo, such as during
tissue injury and inflammation. In this report, the relative susceptibility of each of the major …

Rapid phagocytosis of apoptotic cells is thought to limit the development of inflammation and
autoimmune disease. Serum enhances macrophage phagocytosis of apoptotic cells. Here …

There now exists a bewildering array of biological processes in which free radicals have
been implicated ( 1 ), and we assume that enzymes and structural proteins may be attacked …

Injection of mineral oils such as pristane into the peritoneal cavities of BALB/c mice results in
a chronic peritonitis associated with high tissue levels of interleukin 6 (IL-6). Here we show …

Apoptosis and necrosis are two forms of cell death that are induced under different conditions
and that differ in morphological and biochemical features. In this report, we show that, in …