Aromatic substituent constants for structure-activity correlations
…, SH Unger, KH Kim, D Nikaitani, EJ Lien - Journal of medicinal …, 1973 - ACS Publications
Methods 1. Hydrophobic Parameters. Log P values have been determined as previously
described. 50 In general, at least
described. 50 In general, at least
Quantitative structure-activity relationship analysis of phenolic antioxidants
EJ Lien, S Ren, HH Bui, R Wang - Free Radical Biology and Medicine, 1999 - Elsevier
In this report, the quantitative structure-activity relationship (QSAR) analyses of substituted
phenols, vitamin E derivatives and flavonoids are presented. Two models have been derived …
phenols, vitamin E derivatives and flavonoids are presented. Two models have been derived …
Synthesis, biological evaluation, and quantitative structure− activity relationship analysis of new Schiff bases of hydroxysemicarbazide as potential antitumor agents
…, C Csipke, ZA Tokes, EJ Lien - Journal of medicinal …, 2002 - ACS Publications
Thirty Schiff bases of hydroxysemicarbazide (Ar−CH NNHCONHOH) have been synthesized
and tested against L1210 murine leukemia cells. The IC 50 values were found to be in a …
and tested against L1210 murine leukemia cells. The IC 50 values were found to be in a …
Chemical and pharmacological investigations of Epimedium species: A survey
H Wu, EJ Lien, LL Lien, RM Schultz, VJ Ram… - Progress in Drug …, 2003 - Springer
More than 130 different compounds have been identified from over 16 species of the
Epimedium genus of the Berberidaceae family. Eight of these species have been used in the …
Epimedium genus of the Berberidaceae family. Eight of these species have been used in the …
Design, synthesis, testing, and quantitative structure-activity relationship analysis of substituted salicylaldehyde Schiff bases of 1-amino-3-hydroxyguanidine tosylate …
PH Wang, JG Keck, EJ Lien… - Journal of medicinal …, 1990 - ACS Publications
Further modifications of the structural features ofSchiff bases of hydroxyaminoguanidines (SB-HAG)
led to nine substituted salicylaldehyde Schiff bases of HAG (SSB-HAG) derivatives …
led to nine substituted salicylaldehyde Schiff bases of HAG (SSB-HAG) derivatives …
Use of dipole moment as a parameter in drug–receptor interaction and quantitative structure–activity relationship studies
EJ Lien, ZR Guo, RL Li, CT Su - Journal of pharmaceutical sciences, 1982 - Elsevier
The theoretical basis for using dipole moment as a free-energy related parameter in
studying drug-receptor interaction and quantitative structure-activity relationship (QSAR) is …
studying drug-receptor interaction and quantitative structure-activity relationship (QSAR) is …
Design, synthesis and pharmacological activities of 2-substituted 4-phenylquinolines as potential antidepressant drugs
…, MA Abdelkader, EJ Lien - Journal of medicinal …, 1985 - ACS Publications
This work represents the design, synthesis, and pharmacological testing of 4-phenylquinoline
derivatives as potential antidepressants. Various modifications of substituents at the 2-…
derivatives as potential antidepressants. Various modifications of substituents at the 2-…
Novel N-hydroxyguanidine derivatives as anticancer and antiviral agents
AW Tai, EJ Lien, MMC Lai… - Journal of medicinal …, 1984 - ACS Publications
Hydroxyguanidine contains both features of guanidine and hydroxyurea and has antiviral
and anticancer activities both in vitro and in vivo. In order to enhance the antiviral and …
and anticancer activities both in vitro and in vivo. In order to enhance the antiviral and …
Inhibition of herpes simplex virus type 1 and adenovirus type 5 by heterocyclic Schiff bases of aminohydroxyguanidine tosylate
A Das, MD Trousdale, S Ren, EJ Lien - Antiviral Research, 1999 - Elsevier
Eleven heterocyclic Schiff bases of aminohydroxyguanidine tosylate (SB-AHGs), compounds
I–XI, were tested for antiviral activity against herpes simplex virus type 1 (HSV-1) and …
I–XI, were tested for antiviral activity against herpes simplex virus type 1 (HSV-1) and …
Immunostimulating Polysaccharides from Panax notoginseng
H Gao, F Wang, EJ Lien, MD Trousdale - Pharmaceutical research, 1996 - Springer
Purpose. The main purpose of this study is to prepare and characterize polysaccharides from
Panax notoginseng, investigate their effects on immune system in vitro in order to find new …
Panax notoginseng, investigate their effects on immune system in vitro in order to find new …