In recent years, there has been a surge in the research and development of novel
molecules as potential therapeutic alternatives to traditional treatments (such as intravenous …

… Exposure of the endoperoxide to 37C led to the inactivation of enveloped viruses due
exclusively to the action of the 1O2 generated (Käsermann and Kempf unpublished data). However…

… Whereas some effector mechanisms of IgG relevant to autoimmune diseases may be F(ab′)
2 -mediated, eg blocking/neutralization of receptors, cytokines, anaphylatoxins and …

Photodynamic reactions induced by singlet oxygen-generating agents are known to inactivate
enveloped viruses. In this report we demonstrate that the water-insoluble photosensitizer …

… To investigate this paradigm in CAbIA we first compared IgG Fc and F(ab′) 2 fractions and
found that the protective activity was also confined to the Fc portion in this model, whereas F(…

BACKGROUND: Sialylation of the N‐linked glycan on asparagine‐297 within the Fc region
of intravenous gammaglobulins (IVIgs) was shown to be necessary for efficacy of IVIg in the …

It has been proposed that the anti-inflammatory effects of intravenous immunoglobulin (IVIG)
might be due to the small fraction of Fc-sialylated IgG. In this study we biochemically and …

… that were tested by bioassay in animals were also analyzed by Western blot using proteinase
K (PK) resistant prion protein PrP res as a surrogate marker as described by Käsermann …

Background Recurrent and persistent infections are known to affect airways of patients with
Primary Immunodeficiency despite appropriate replacement immunoglobulin serum levels. …

Objective Plasmacytoid dendritic cells (PDCs) produce high concentrations of interferon‐α (IFNα)
following exposure to immune complexes containing nucleic acids. We previously …