Dissolution tests are used for many purposes in the pharmaceutical industry: in the
development of new products, for quality control and, to assist with the determination of …

In the last decade, the regulatory bioequivalence (BE) requirements of drug products have
undergone major changes. The introduction of the biopharmaceutics drug classification …

Prodrugs are an established concept to overcome barriers to a drug’s usefulness. In Germany,
about 6.9% of all marketed medicines can be classified as prodrugs, an estimate based …

… PJ Sinko, GD Leesman, and GL Amidon, Predicting fraction dose absorbed in humans
using a macroscopic mass balance approach, Pharm. Res., 8:979-988 (1991). 3. …

Purpose. To investigate the effect of microparticle size on gastrointestinal tissue uptake.
Methods. Biodegradable microparticles of various sizes using polylactic polyglycolic acid (50:50) …

Purpose. To study the uptake of biodegradable microparticles in Caco-2 cells. Methods.
Biodegradable microparticles of polylactic polyglycolic acid co-polymer (PLGA 50:50) of mean …

Provides a sound theoretical basis for understanding chemical kinetics and its uses in studying
drug stability. Treats the calculations, approximations, and estimates that are useful to the …

The purpose of this study is to provisionally classify, based on the Biopharmaceutics
Classification System (BCS), drugs in immediate-release dosage forms that appear on the World …

… RL Oberle and GL Amidon. The influence of variable gastric emptying and intestinal transit
… Lobenberg and GL Amidon. Modern bioavailability, bioequivalence and biopharmaceutics …

Orally administered, immediate-release (IR) drug products in the top 200 drug product lists
from the United States (US), Great Britain (GB), Spain (ES), and Japan (JP) were provisionally …