Objective: Autoinjectors are a convenient and efficient way to self-administer subcutaneous
injections of biopharmaceuticals. Differences in device mechanical design can affect the …

Purpose The objective of this work was to systematically evaluate the effects of formulation
composition on subcutaneous injection site pain (ISP) using matrices comprising of common …

Use of prefilled syringes to self-administer biologics via subcutaneous administration provides
convenience to patients. The barrel interior of prefilled syringes is typically coated with …

The collapse of cavitation bubbles induced by abrupt acceleration of the syringe in an
autoinjector device can lead to protein aggregation. The details of bubble dynamics are …

Purpose Interface motion and hydrodynamic shear of the liquid slosh during the insertion of
syringes upon autoinjector activation may damage the protein drug molecules. …

Recombinant human hyaluronidase PH20 (rHuPH20) facilitates subcutaneous (SC) delivery
of co-administered therapeutic agents by locally and transiently degrading hyaluronan in …

Purpose To evaluate the clinical feasibility and tolerability of large volume subcutaneous
delivery at different injection depths for lean and non-lean subjects. Methods A single-center, …

Current parenteral containers used for the storage and delivery of protein-based drugs,
contain silicone oil which may seep into the protein solution and can result in adsorption, …

There has been a significant progress in the clinical applications of nucleic acids, including
RNA and DNA, for treating human diseases. Antisense oligonucleotide was first approved to …

This study aimed to elucidate the mechanisms and kinetics of coating failure for enteric
coated beads exposed to high-humidity conditions at different storage temperatures. Enteric …