In recent years, significant progress has been made in the studies of the spring-driven
autoinjector, leading to an improved understanding of this device and its interactions with tissue …

This study focuses on developing a predictive dynamic model for spring-driven autoinjectors.
The values of unknown physical parameters, such as the heat convection coefficient and …

Previous studies revealed the impact of formulation factors (excipients and pH) on the
functionality of prefilled syringes. Surfactant, a critical formulation component for therapeutic …

Accurate injection time prediction is essential in developing spring-driven autoinjector devices
since the drug delivery is expected to finish within seconds to bring convenience, reduce …

Purpose. The purpose of this work was to image crystalline drug nanoparticles from a liquid
dispersion and in a solid dosage form for the determination of size, shape, and distribution. …

Given the surging interest in developing prefilled syringe and autoinjector combination
products, investment in an early compatibility assessment is critical to prevent unwarranted drug/…

Previous studies have shown that parenteral formulation excipients can interact with the
silicone oil in prefilled syringes, thereby causing variations in glide force that affect the …

The collapse of cavitation bubbles induced by abrupt acceleration of the syringe in an
autoinjector device can lead to protein aggregation. The details of bubble dynamics are …

Cavitation, the formation and collapse of vapor-filled bubbles, poses a problem in spring-driven
autoinjectors (AIs). It occurs when the syringe accelerates abruptly during activation, …

The manufacture of drug delivery devices requires the assembly of multiple device components
with the corresponding drug products, often with an abundance of data being collected …