Absorption of polyethylene glycols 600 through 2000: the molecular weight dependence of gastrointestinal and nasal absorption

MD Donovan, GL Flynn, GL Amidon - Pharmaceutical research, 1990 - Springer
Polyethylene glycols (PEGs) 600,1000, and 2000 were used to study the molecular weight
permeability dependence in the rat nasal and gastrointestinal mucosa. Absorption of the …

Transdermal delivery of narcotic analgesics: pH, anatomical, and subject influences on cutaneous permeability of fentanyl and sufentanil

SD Roy, GL Flynn - Pharmaceutical research, 1990 - Springer
The permeation of fentanyl and sufentanil through cadaver skin membranes was investigated
using in vitro diffusion cell techniques. Neither drug influenced the permeation of the other …

Bioequivalence of topical dermatological dosage forms–methods of evaluation of bioequivalence

VP Shah, GL Flynn, A Yacobi, HI Maibach… - Skin Pharmacology and …, 1998 - karger.com
The 3-day AAPS/FDA Workshop on ‘Bioequivalence of Topical Dermatological Dosage
Forms–Methods of Evaluating Bioequivalence’, held on September 4–6, 1996 in Bethesda, Md., …

Transfollicular drug delivery

AC Lauer, LM Lieb, C Ramachandran, GL Flynn… - Pharmaceutical …, 1995 - Springer
The hair follicle, hair shaft, and sebaceous gland collectively form what is recognized as the
pilosebaceous unit. This complex, three-dimensional structure within the skin possesses a …

Influence of liposomal drug entrapment on percutaneous absorption

MG Ganesan, ND Weiner, GL Flynn, NFH Ho - International journal of …, 1984 - Elsevier
Results of permeation experiments involving finite dose diffusion cells with hairless mouse
skin as the membrane indicate that neither intact liposomes nor the phospholipid of which …

Solubility and related physicochemical properties of narcotic analgesics

SD Roy, GL Flynn - Pharmaceutical research, 1988 - Springer
The physicochemical properties of select opioid and anilinopiperidine narcotic analgesics
were investigated. The solubilities of the narcotics in hexane and water and, for morphine, in …

Controlled transdermal delivery of fentanyl: Characterizations of pressure‐sensitive adhesives for matrix patch design

SD Roy, M Gutierrez, GL Flynn… - Journal of …, 1996 - Wiley Online Library
Transdermal delivery of fentanyl from various adhesive matrix formulations to achieve a
steady‐state skin flux was investigated. For this purpose, various pressure‐sensitive adhesives …

Hydration and percutaneous absorption: I. Influence of hydration on alkanol permeation through hairless mouse skin

CR Behl, GL Flynn, T Kurihara, N Harper… - Journal of Investigative …, 1980 - Elsevier
A method to study the influence of hydration on skin permeability where the skin is immersed
in saline for up to 30 hr and under circumstances where a steady state rate of permeation …

Physicochemical characterization of the human nail: permeation pattern for water and the homologous alcohols and differences with respect to the stratum corneum

KA Walters, GL Flynn, JR Marvel - Journal of Pharmacy and …, 1983 - Wiley Online Library
In order to develop a basic concept of the permeability of the human nail plate and thus create
a better understanding of the toxic potentials and therapeutic possibilities of substances …

Permeation of hairless mouse skin I: Experimental methods and comparison with human epidermal permeation by alkanols

H Durrheim, GL Flynn, WI Higuchi, CR Behl - Journal of Pharmaceutical …, 1980 - Elsevier
The permeation of intact hairless mouse skin by alkanols was studied. The method is described,
and data for the quasi-steady-state and nonstationary-state aspects of mass transfer are …