The extent to which electrochemistry on‐line with electrospray mass spectrometry can be
used to mimic cytochrome P450 catalyzed oxidations has been investigated. Comparisons on …

We determined the cytotoxicity of some artemisinin derivatives against EN2 tumor cells using
the MTT assay. Artemisinin (1) was clearly more cytotoxic than deoxyartemisinin (2), which …

High shear granulation is a complex unit operation with several interacting process
parameters. No generally accepted real-time in-line tools are available to gain insight into this …

This study deals with the cytotoxicity of helenanolide-type (10α-methylpseudoguaianolide)
sesquiterpene lactones. We determined the influence of substitution patterns on the toxicity of …

Benzopyranoxazine (+)-7 (PD 128907) is the most dopamine (DA) D 3 receptor-selective
agonist presently known. The only structural feature which distinguishes 7 from the analogous …

Abstract Formulation of an amorphous solid dispersion (ASD) is one of the methods commonly
considered to increase the bioavailability of a poorly water-soluble small-molecule active …

Process‐induced transformations are very important to control during pharmaceutical
manufacturing because they may change the properties of the active pharmaceutical ingredient in …

The selective D 3 -dopamine receptor agonist 4aR,10bR-(+)-trans-3,4,4a,10b-tetrahydro-4-[N-propyl-2,3-
3 H]-2H,5H-[1]benzopyrano[4,3-b]-1,4-oxazin-9-ol ([ 3 H]PD 128907) was used …

A series of 2- or 8-trifluoromethylsulfonyloxy (TfO) and 2- or 8-methylsulfonyloxy (MsO) 11-piperazinyldibenzodiazepines,
-oxazepines, and -thiazepines were synthesized and …

The aim of these studies was to investigate the scope and limitations of electrochemistry on‐line
with mass spectrometry as a quick and convenient way to mimic phase I oxidative …