Pre-filled syringes (PFS) and auto-injection devices with cartridges are increasingly used for
parenteral administration. To assure functionality, silicone oil is applied to the inner surface …

A significant number of therapeutic proteins are marketed as pre-filled syringes or other drug/device
combination products and have been safely used in these formats for years. Silicone …

Biopharmaceutical products are increasingly commercialized as drug/device combinations
to enable self-administration. Siliconization of the inner syringe/cartridge glass barrel for …

Combination products have become popular formats for the delivery of parenteral medications.
Bake-on siliconization of glass syringes or cartridges allows good piston break-loose and …

MabThera is an essential component of the standard-of-care regimens in the treatment of
non-Hodgkin lymphoma and Chronic Lymphatic Leukemia. MabThera for subcutaneous …

Herceptin is a humanized monoclonal antibody that selectively binds to the extracellular
domain of human epidermal growth factor receptor 2 (HER2). Herceptin has an important role in …

The fill-finish process of highly concentrated protein formulations poses several technical
challenges and, in particular, the filling process is critical to ensure filling accuracy. As highly …

In this work, the dependence of transdermal delivery of hydrophilic drugs on mass fraction
and microstructure of dispersed phase of multi-phase dermatological o/w formulations was …

Introduction: To be absorbed from the gastrointestinal tract, a drug has to be sufficiently soluble,
because, with some exceptions, passive diffusion of dissolved drug molecules from high …

The objective of this thesis was to develop a spectrophotometric methodology for simultaneous
determination of a sunscreening agent and relative stratum corneum tissue density in …