User profiles for Henning Gieseler

PD Dr. Henning Gieseler

Friedrich-Alexander University (FAU) Erlangen-Nürnberg
Verified email at fau.de
Cited by 2004

Evaluation of tunable diode laser absorption spectroscopy for in‐process water vapor mass flux measurements during freeze drying

H Gieseler, WJ Kessler, M Finson, SJ Davis… - Journal of …, 2007 - Elsevier
The goal of this work was to demonstrate the use of Tunable Diode Laser Absorption
Spectroscopy (TDLAS) as a noninvasive method to continuously measure the water vapor …

Freeze-dry microscopy of protein/sugar mixtures: drying behavior, interpretation of collapse temperatures and a comparison to corresponding glass transition data

E Meister, H Gieseler - Journal of pharmaceutical sciences, 2009 - Elsevier
The purpose of this study is to investigate the change in collapse appearance and temperature
of protein/sugar mixtures as a function of nucleation temperature (T n ), sublimation …

Freeze-drying of nanosuspensions, 1: freezing rate versus formulation design as critical factors to preserve the original particle size distribution

…, S Inghelbrecht, A Arien, H Gieseler - Journal of pharmaceutical …, 2011 - Elsevier
It has been recently reported in the literature that using a fast freezing rate during freeze-drying
of drug nanosuspensions is beneficial to preserve the original particle size distribution. …

Evaluation of a new wireless temperature remote interrogation system (TEMPRIS) to measure product temperature during freeze drying

S Schneid, H Gieseler - Aaps PharmSciTech, 2008 - Springer
The purpose of this research was to evaluate a new wireless and battery-free sensor
technology for invasive product temperature measurement during freeze-drying. Product …

Impact of payload hydrophobicity on the stability of antibody–drug conjugates

…, M Winzer, J Tonillo, C Weber, H Gieseler - Molecular …, 2018 - ACS Publications
In silico screening of toxin payloads typically employed in ADCs revealed a wide range of
hydrophobicities and sizes as measured by logP and topological polar surface area (tPSA) …

Use of manometric temperature measurement (MTM) and SMART™ freeze dryer technology for development of an optimized freeze‐drying cycle

H Gieseler, T Kramer, MJ Pikal - Journal of Pharmaceutical …, 2007 - Wiley Online Library
This report provides, for the first time, a summary of experiments using SMART™ Freeze Dryer
technology during a 9 month testing period. A minimum ice sublimation area of about 300 …

Non-invasive product temperature determination during primary drying using tunable diode laser absorption spectroscopy

SC Schneid, H Gieseler, WJ Kessler… - Journal of pharmaceutical …, 2009 - Elsevier
The goal of this work was to demonstrate the application of Tunable Diode Laser Absorption
Spectroscopy (TDLAS) as a non-invasive method to determine the average product …

Optimization of the secondary drying step in freeze drying using TDLAS technology

SC Schneid, H Gieseler, WJ Kessler, SA Luthra… - Aaps Pharmscitech, 2011 - Springer
The secondary drying phase in freeze drying is mostly developed on a trial-and-error basis
due to the lack of appropriate noninvasive process analyzers. This study describes for the …

The effect of mannitol crystallization in mannitol–sucrose systems on LDH stability during freeze-drying

A Al-Hussein, H Gieseler - Journal of pharmaceutical sciences, 2012 - Elsevier
The objective of this study was to investigate the influence of mannitol crystallization and the
effect of annealing on the stability of lactate dehydrogenase (LDH) during freeze-drying. For …

Predicting critical micelle concentration and micelle molecular weight of polysorbate 80 using compendial methods

AC Braun, D Ilko, B Merget, H Gieseler… - European Journal of …, 2015 - Elsevier
This manuscript addresses the capability of compendial methods in controlling polysorbate
80 (PS80) functionality. Based on the analysis of sixteen batches, functionality related …