Technology, applications, and process challenges of dual chamber systems

T Werk, IS Ludwig, J Luemkemann, HC Mahler… - Journal of …, 2016 - Elsevier
Dual-chamber systems provide an option as a drug and device combination product, when
home care and emergency lyophilized products are intended. Nevertheless, until today, there …

The effect of formulation, process, and method variables on the reconstitution time in dual chamber syringes

T Werk, IS Ludwig, HC Mahler… - PDA journal of …, 2016 - journal.pda.org
Reconstitution time of dried products is influenced by various factors including formulation,
process, and reconstitution method itself. This manuscript describes factors affecting …

[HTML][HTML] Low volume aseptic filling: Impact of pump systems on shear stress

T Dreckmann, J Boeuf, IS Ludwig, J Lümkemann… - European Journal of …, 2020 - Elsevier
… 200 µL of the liposomal preparation was pipetted on the plate and subjected to shear rates
from 10 to 2000 1/s for 30 s at 20 C. The shearing time was experimentally determined. After …

[PDF][PDF] New processes for freeze-drying in dual chamber systems

T Werk, IS Ludwig, J Luemkemann… - PDA J. Pharm. Sci …, 2016 - researchgate.net
… Cohen’s effect size d compares the two mean sublimation rates (M) of a collection of edge
and 17 center containers relative to their pooled standard deviations (sd). A larger absolute …

[PDF][PDF] Low-volume aseptic filling using a linear peristaltic pump

T Dreckmann, IS Ludwig, J Luemkemann… - PDA J. Pharm. Sci …, 2021 - researchgate.net
… Tim Dreckmann a,b , Imke-Sonja Ludwig a , Jörg Lümkemann a , Jörg Huwyler b a F.
Hoffmann-La Roche Ltd., … The filling speed was set to 20 s/filling event, at 30 Hz (433 ms). …

[PDF][PDF] Assessment of sensor concepts for a 100% in-process control

T Dreckmann, IS Ludwig, J Luemkemann - researchgate.net
… ’s capacitance, which is caused by the liquid’s permittivity. The sensor was tested over a
volume range of 12.3–97.9 µL. The results for the representative volume of 60 µL showed an …

A method to determine the kinetics of solute mixing in liquid/liquid formulation dual-chamber syringes

T Werk, HC Mahler, IS Ludwig… - PDA journal of …, 2017 - journal.pda.org
Dual-chamber syringes were originally designed to separate a solid substance and its
diluent. However, they can also be used to separate liquid formulations of two individual drug …

Assessment of sensor concepts for 100% in-process control of low-volume aseptic fill-finish processes

…, J TrÖndle, A Ernst, J Huwyler, IS Ludwig… - PDA Journal of …, 2020 - journal.pda.org
The pharmaceutical industry is currently being confronted with new and complex challenges
regarding the aseptic filling of parenterals, especially monoclonal antibodies, particularly for …

[HTML][HTML] Effect evaluation of a tele-neurologic intervention in primary care in a rural area in Germany—the NeTKoH study protocol of a stepped-wedge cluster …

…, AS Oliveira Gonçalves, RS Schulz, S Kiel… - BMC Health Services …, 2023 - Springer
… a stepped-wedge design involving 33 outpatient general practitioner’s (GP) offices (clusters)
in a … The primary outcome is the proportion of neurologic problems being solved at the GP’s

Drying, film formation and open time of aqueous polymer dispersions

I Ludwig, W Schabel, P Ferlin, JC Castaing… - The European physical …, 2009 - Springer
Industry has invested significant time and effort to develop water-based paints and varnishes,
that show a drying behaviour comparable to that of established solvent-based polymer …