The human cytomegalovirus glycoprotein, UL16, binds to two members of a novel family of
molecules, the ULBPs, and to the MHC class I homolog, MICB. The ULBPs are GPI-linked …

The pro-inflammatory cytokine interleukin (IL)-6 (refs. 1–5) can bind to cells lacking the IL-6
receptor (IL-6R) when it forms a complex with the soluble IL-6R (sIL-6R)(trans signaling) 5, 6, …

Recombinant protein therapeutics, vaccines, and plasma products have a long record of
safety. However, the use of cell culture to produce recombinant proteins is still susceptible to …

The Epstein-Barr virus (EBV) gH-gL complex includes a third glycoprotein, gp42. gp42
binds to HLA class II on the surfaces of B lymphocytes, and this interaction is essential for …

A functionally and structurally diverse group of transmembrane proteins including transmembrane
forms of mediators or receptors can be proteolytically cleaved to form soluble growth …

New members of the extended MHC class I‐like family were identified based on their ability
to bind human cytomegalovirus glycoprotein UL16 and/or their mutual homology. Soluble …

An analysis of the mechanism of generation of the soluble interleukin-6 receptor (IL-6R) has
been performed. The membrane-bound receptor is proteolytically cleaved to release a …

We introduce a procedure for the rapid generation of fully human antibodies derived from “Fab-on-phage”
display libraries. The technology is based on the compatibility of display …

Signal transduction in response to interleukin‐6 (IL‐6) requires binding of the cytokine to its
receptor (IL‐6R) and subsequent homodimerization of the signal transducer gp130. The …

Interleukin-6 (IL-6) and ciliary neurotrophic factor (CNTF) are "4–helical bundle" cytokines of
the IL–6 type family of neuropoietic and hematopoietic cytokines. IL-6 signals by induction …