Complex dosing regimens, costs, side effects, biodistribution limitations, and variable drug
pharmacokinetic patterns have affected the long-term efficacy of antiretroviral medicines. To …

There has been growing interest in nanoparticles as an approach to formulate poorly
soluble drugs. Besides enhanced dissolution rates, and thereby, improved bioavailability, …

Antiretroviral therapy (ART) shows variable blood-brain barrier penetration. This may affect
the development of neurological complications of HIV infection. In attempts to attenuate viral …

The goal of this research was to evaluate an intravenous itraconazole nanosuspension
dosage form, relative to a solution formulation, in the rat. Itraconazole was formulated as a …

The effectiveness of anti-retroviral therapies (ART) depends on its ultimate ability to clear
reservoirs of continuous human immunodeficiency virus (HIV) infection. We reasoned that a …

Development of injectable formulations typically requires specific considerations on the type
and quality of excipients used. The criteria for excipient selection depend on a number of …

Freezing of commonly used parenteral products to increase pharmaceutical stability for cost-saving
purposes is a common practice in patient care. However, frozen meropenem, a …

The stability of an antibiotic formulation (clindamycin phosphate in dextrose), which is stable
at room temperature, was assessed by nonisothermal kinetic analysis at elevated …

“Parenteral” is defined 1 as “situated or occurring outside the intestine, and especially
introduced otherwise than by way of the intestines”—pertaining to essentially any administration …

The Kentucky Geological Survey has been conducting studies in the Eastern Kentucky Coal
Field since 1980 to determine the various hydrogeologic conditions that exist in the region. …