The quality-by-design (QbD) approach is widely utilized for developing and validating
manufacturing processes for drug substances as well as drug products. This paper discusses the …

The identification of critical process parameters in biologics and small molecule process
development is a key element of quality by design. The objectivity and consistency of …

Rare genetic diseases affect millions, and identifying causal DNA variants is essential for
patient care. Therefore, it is imperative to estimate the effect of each independent variant and …

… Jean-Claude Walser (GDC Zurich) for the support on bioinformatics, and Janine Burren (Statistical
Consulting Group ETH) for advices on statistics. …

Most patients with rare diseases do not receive a molecular diagnosis and the aetiological
variants and causative genes for more than half such disorders remain to be discovered 1 . …

… my time here in Switzerland, I also want to thank Nathalie Vonrüti, Nadine Peneder und
Janine Burren. I would also like to thank all my study friends for their advice, personal and …

Primary immunodeficiency (PID) is characterized by recurrent and often life-threatening
infections, autoimmunity and cancer, and it poses major diagnostic and therapeutic challenges. …

In this Article, the citation to the related Nature paper by Ouwehand and colleagues 1 (ref. 38
of the Article) should have been updated, instead of referring to the bioRxiv preprint version …

Quantification of turnover of inorganic soil phosphorus (P) pools is essential to improve our
understanding of P cycling in soil–plant systems and improve representations of the P cycle …

… Jose Rojas-Camayo for sharing the centiles of his valuable dataset, Janine Burren for her
valueable input on statistics and data representation, and Dr. Urs Frey for helpful comments on …