Efficacy and safety of ustekinumab, an IL-12 and IL-23 inhibitor, in patients with active systemic lupus erythematosus: results of a multicentre, double-blind, phase 2 …
…, B Zhou, B Hsu, M Chevrier, M Triebel, JL Jordan… - The Lancet, 2018 - thelancet.com
Background Ustekinumab is a monoclonal antibody targeting interleukin (IL)-12 and IL-23
and is approved for the treatment of plaque psoriasis, psoriatic arthritis, and Crohn's disease. …
and is approved for the treatment of plaque psoriasis, psoriatic arthritis, and Crohn's disease. …
[HTML][HTML] LL37 and cationic peptides enhance TLR3 signaling by viral double-stranded RNAs
…, K Bhardwaj, CT Ranjith-Kumar, Y Wen, JL Jordan… - PloS one, 2011 - journals.plos.org
Background Toll-like Receptor 3 (TLR3) detects viral dsRNA during viral infection. However,
most natural viral dsRNAs are poor activators of TLR3 in cell-based systems, leading us to …
most natural viral dsRNAs are poor activators of TLR3 in cell-based systems, leading us to …
[HTML][HTML] IL-23 reshapes kidney resident cell metabolism and promotes local kidney inflammation
…, IE Stillman, P Rosenstiel, J Jordan… - The Journal of …, 2021 - Am Soc Clin Investig
Interstitial kidney inflammation is present in various nephritides in which serum interleukin
23 (IL-23) is elevated. Here we showed that murine and human renal tubular epithelial cells (…
23 (IL-23) is elevated. Here we showed that murine and human renal tubular epithelial cells (…
[HTML][HTML] The human antimicrobial peptide LL-37, but not the mouse ortholog, mCRAMP, can stimulate signaling by poly (I: C) through a FPRL1-dependent pathway
D Singh, R Qi, JL Jordan, L San Mateo… - Journal of Biological …, 2013 - ASBMB
LL-37 is an antimicrobial peptide produced by human cells that can down-regulate the
lipopolysaccharide-induced innate immune responses and up-regulate double-stranded (ds) RNA…
lipopolysaccharide-induced innate immune responses and up-regulate double-stranded (ds) RNA…
Mycoplasma pneumoniae Protein P30 Is Required for Cytadherence and Associated with Proper Cell Development
CE Romero-Arroyo, J Jordan, SJ Peacock… - Journal of …, 1999 - Am Soc Microbiol
The attachment organelle of Mycoplasma pneumoniae is a polar, tapered cell extension
containing an intracytoplasmic, electron-dense core. This terminal structure is the leading end in …
containing an intracytoplasmic, electron-dense core. This terminal structure is the leading end in …
Mycoplasma pneumoniae host–pathogen studies in an air–liquid culture of differentiated human airway epithelial cells
TM Krunkosky, JL Jordan, E Chambers… - Microbial …, 2007 - Elsevier
The interaction between Mycoplasma pneumonaie and the airway epithelium in vivo is
complex and multifaceted. While multiple in vitro studies have been conducted studying this …
complex and multifaceted. While multiple in vitro studies have been conducted studying this …
Mycoplasma pneumoniae Community Acquired Respiratory Distress Syndrome toxin expression reveals growth phase and infection‐dependent regulation
…, S Balasubramanian, M Cagle, JL Jordan… - Molecular …, 2010 - Wiley Online Library
Mycoplasma pneumoniae causes acute and chronic respiratory infections, including
tracheobronchitis and community acquired pneumonia, and is linked to asthma and an array of extra…
tracheobronchitis and community acquired pneumonia, and is linked to asthma and an array of extra…
Terminal organelle development in the cell wall-less bacterium Mycoplasma pneumoniae
BM Hasselbring, JL Jordan… - Proceedings of the …, 2006 - National Acad Sciences
Mycoplasmas are cell wall-less bacteria considered among the smallest and simplest
prokaryotes known, and yet several species including Mycoplasma pneumoniae have a …
prokaryotes known, and yet several species including Mycoplasma pneumoniae have a …
Lateral clustering of TLR3: dsRNA signaling units revealed by TLR3ecd: 3Fabs quaternary structure
…, A Teplyakov, Y Zhao, RJ Lamb, JL Jordan… - Journal of molecular …, 2012 - Elsevier
Toll-like receptor 3 (TLR3) recognizes dsRNA and initiates an innate immune response
through the formation of a signaling unit (SU) composed of one double-stranded RNA (dsRNA) …
through the formation of a signaling unit (SU) composed of one double-stranded RNA (dsRNA) …
[HTML][HTML] Human interferon-ϵ and interferon-κ exhibit low potency and low affinity for cell-surface IFNAR and the poxvirus antagonist B18R
BD Harris, J Schreiter, M Chevrier, JL Jordan… - Journal of Biological …, 2018 - ASBMB
IFNϵ and IFNκ are interferons that induce microbial immunity at mucosal surfaces and in the
skin. They are members of the type-I interferon (IFN) family, which consists of 16 different …
skin. They are members of the type-I interferon (IFN) family, which consists of 16 different …