Fc receptor–like (FCRL) 5 regulates B cell Ag receptor signaling and has been reported to
bind aggregated IgG. Using surface plasmon resonance, we analyzed the interaction of native …

The biological roles of B cell membrane proteins in the FCRL family are enigmatic. FCRL
proteins, including FCRL5, were shown to modulate early BCR signaling, although the …

Viral contamination is a potential risk of using biotechnology products derived from mammalian
cell lines. Therefore, to provide assurance of the safety of these products regarding …

Human Fc receptor-like 3 (FCRL3) is an orphan receptor expressed by lymphocytes, including
regulatory T cells. FCRL3 is implicated in several autoimmune diseases; however, its …

Atypical memory B cells accumulate in chronic infections and autoimmune conditions, and
commonly express FCRL4 and FCRL5, respective IgA and IgG receptors. We characterized …

The B-cell response to antigen is critically regulated by co-receptors. CD21 (complement
receptor 2) amplifies the response to antigen linked to its ligands, specific C3 fragments. In …

Fc-receptor homolog 5 (FcRH5) is a recently identified B-cell membrane protein of unknown
function. In Burkitt lymphoma cell lines with chromosome 1q21 abnormalities, FcRH5 …

Fc receptor-like (FCRL) proteins are novel regulators of the B cell response to antigen.
Human FCRL5 binds intact IgG and modifies the strength of antigen receptor (BCR) signaling. …

Demonstration of effective and consistent viral clearance by small scale models of downstream
processing, typically cited as logarithmic reduction value (LRV), is an important safety …

Human Fc receptor-like 5 (FCRL5) is a novel IgG receptor. We reported that IgG2 samples
display a thousand-fold range affinity for FCRL5, indicating that attributes beyond the isotype …