Phylogeny of the genustrichodermabased on sequence analysis of the internal transcribed spacer region 1 of the rDNA cluster

J Kindermann, Y El-Ayouti, GJ Samuels… - Fungal Genetics and …, 1998 - Elsevier
Sequences of the internal transcribed spacer region 1 (ITS1) of the ribosomal DNA were
used to determine the phylogenetic relationships of species ofTrichodermasect.Pachybasium.…

The function of CreA, the carbon catabolite repressor of Aspergillus nidulans, is regulated at the transcriptional and post‐transcriptional level

…, HK Horvath, BM Abdallah, J Kindermann… - Molecular …, 1999 - Wiley Online Library
The creA gene of A. nidulans encodes a wide‐domain regulatory protein mediating carbon
catabolite repression. Northern blot analysis of creA mRNA revealed a complex expression …

West Nile virus and the safety of plasma derivatives: verification of high safety margins, and the validity of predictions based on model virus data

TR Kreil, A Berting, O Kistner, J Kindermann - Transfusion, 2003 - Wiley Online Library
BACKGROUND: During the 2002 West Nile virus (WNV) epidemic in the US, virus transmission
through solid organ transplantation and transfusion of blood components was observed. …

Truly continuous low pH viral inactivation for biopharmaceutical process integration

…, A Flicker, J Kindermann… - Biotechnology and …, 2020 - Wiley Online Library
Continuous virus inactivation (VI) has received little attention in the efforts to realize fully
continuous biomanufacturing in the future. Implementation of continuous VI must assure a …

Development of a Triton X‐100 replacement for effective virus inactivation in biotechnology processes

JB Farcet, J Kindermann, M Karbiener… - Engineering …, 2019 - Wiley Online Library
After the transmission of human viruses through plasma derivatives had been recognized in
the early 1980s, virus inactivation and then removal steps have been implemented into their …

[HTML][HTML] Virus disinfection for biotechnology applications: Different effectiveness on surface versus in suspension

J Kindermann, M Karbiener, SM Leydold, S Knotzer… - Biologicals, 2020 - Elsevier
Virus contamination events in cell culture-based biotechnology processes have occurred
and have had a dramatic impact on the supply of life-saving drugs, and thus on the wellbeing …

[HTML][HTML] Detergent-mediated virus inactivation in biotechnological matrices: More than just CMC

JB Farcet, M Karbiener, L Zelger, J Kindermann… - International Journal of …, 2023 - mdpi.com
For decades, the ability of detergents to solubilize biological membranes has been utilized
in biotechnological manufacturing to disrupt the lipid envelope of potentially contaminating …

Synthesis of “Nereid,” a new phenol‐free detergent to replace Triton X‐100 in virus inactivation

JB Farcet, J Kindermann, M Karbiener… - Journal of Medical …, 2021 - Wiley Online Library
In the 1980s, virus inactivation steps were implemented into the manufacturing of
biopharmaceuticals in response to earlier unforeseen virus transmissions. The most effective …

Chikungunya virus and the safety of plasma products

SM Leydold, MR Farcet, J Kindermann, J Modrof… - …, 2012 - Wiley Online Library
BACKGROUND: Chikungunya virus (CHIKV) outbreaks were previously restricted to parts
of Africa, Indian Ocean Islands, South Asia, and Southeast Asia. In 2007, however, the first …

Use of an internal standard in a closed one-tube RT-PCR for the detection of equine arteritis virus RNA with fluorescent probes

…, D King, T Drew, N Nowotny, J Kindermann… - Veterinary …, 2003 - hal.science
Routine detection of equine arteritis virus (EAV) can be achieved by virus isolation (VI) in cell
culture, or by the amplification of viral genome by molecular methods. To simplify molecular …