To maintain or strengthen their market position, biopharmaceutical producers have to adapt
their production facilities to a drastically changed market environment. Contrary to currently …

Microbial bioproduction of the aromatic acid anthranilate (ortho-aminobenzoate) has the
potential to replace its current, environmentally demanding production process. The host …

The intracellular concentrations of the valine and leucine pathway intermediates in a
Corynebacterium glutamicum strain were measured during a transient state. The data were …

Background To understand the dynamic behavior of cellular systems, mathematical
modeling is often necessary and comprises three steps: (1) experimental measurement of …

The enzyme targets for the rational optimization of a Corynebacterium glutamicum strain
constructed for valine production are identified by analyzing the control of flux in the valine/…

An important problem in systems biology is parameter estimation for biochemical system
models. Our work concentrates on the metabolic subnetwork of the valine and leucine …

Parameter estimation for biochemical model systems has become an important problem in
systems biology. Here we focus on the metabolic subnetwork of the valine and leucine …

The functionality of the intracellular reaction network in a Corynebacterium glutamicum valine
production strain was investigated with special focus on the valine/leucine biosynthesis …

A large number of bulk chemicals that are currently produced by petrochemical processes
can potentially be produced from renewable resources by fermentation. The diversity of …

Bayers vision of the Biofacility of the Future is developed within the Mobidik project. A pilot
plant with a complete production line of monoclonal antibodies from fermentation to final drug …