Drug release from wax matrices I. Analysis of data with first‐order kinetics and with the diffusion‐controlled model

JB Schwartz, AP Simonelli… - Journal of …, 1968 - Wiley Online Library
The release of drug into aqueous media from wax matrices has been investigated using
benzoic acid and salicylic acid as the active ingredients. The data have been examined from the …

Drug–polymer interaction and its significance on the physical stability of nifedipine amorphous dispersion in microparticles of an ammonio methacrylate copolymer …

J Huang, RJ Wigent, JB Schwartz - Journal of Pharmaceutical Sciences, 2008 - Elsevier
Using spectroscopic and thermal analysis, this study investigated drug–polymer interaction
and its significance on the physical stability of drug amorphous dispersion in microparticles …

Nifedipine solid dispersion in microparticles of ammonio methacrylate copolymer and ethylcellulose binary blend for controlled drug delivery: Effect of drug loading on …

…, RJ Wigent, CM Bentzley, JB Schwartz - International journal of …, 2006 - Elsevier
In order to elucidate the controlled-release mechanism of a poorly water-soluble drug from
microparticles of ammonio methacrylate copolymer and ethylcellulose binary blend prepared …

Optimization techniques in pharmaceutical formulation and processing

JB Schwartz, RE O'Connor… - Modern pharmaceutics, 2002 - taylorfrancis.com
A significant portion of this book is devoted to the concepts involved in formulating drug
products in their various forms. Physical, chemical, and biological properties all must be given …

Nifedipine molecular dispersion in microparticles of ammonio methacrylate copolymer and ethylcellulose binary blends for controlled drug delivery: effect of matrix …

J Huang, RJ Wigent, JB Schwartz - Drug development and …, 2006 - Taylor & Francis
The objective of this study is to explore matrix-type microparticles, comprising a solid dispersion
of drug with an ammonio methacrylate copolymer and ethylcellulose binary blend, for …

Melt granulation and heat treatment for wax matrix-controlled drug release

YE Zhang, JB Schwartz - Drug development and industrial …, 2003 - Taylor & Francis
The purpose of this study was to evaluate sustained drug release after melt granulation and
heat treatment. Theophylline (anhydrous) and phenylpropanolamine hydrochloride (PPA) …

Effect of processing methods and heat treatment on the formation of wax matrix tablets for sustained drug release

YE Zhang, R Tchao, JB Schwartz - … development and technology, 2001 - Taylor & Francis
The objective of this study was to evaluate the effects of processing methods and heat treatment
on matrix formation and subsequent drug release from wax matrix tablets for controlled …

Drug release from film-coated chlorpheniramine maleate nonpareil beads: effect of water-soluble polymer, coating level, and soluble core material

L Tang, JB Schwartz, SC Porter… - Pharmaceutical …, 2000 - Taylor & Francis
The purpose of this research was to use a new drug release model to study the effects of
formulation parameters on drug release from a film-coated chlorpheniramine (CPM) nonpareil …

Computer optimization of pharmaceutical formulations I: General procedure

JB Schwartz, JR Flamholz, RH Press - Journal of Pharmaceutical Sciences, 1973 - Elsevier
A technique was developed whereby a formulation with optimum properties, according to
predetermined criteria, can be selected via computer analysis. The results of a statistically …

The binding and disintegrant properties of the corn starch fractions: amylose and amylopectin

JB Schwartz, JA Zelinskie - Drug Development and Industrial …, 1978 - Taylor & Francis
Corn Starch USP consists of the two glucose polymers, amylose and amylopectin, whose
normal ratio is 27%:73%. This study was initiated to determine whether a variation in this ratio …