The delivery of drugs via the mucous membranes lining the oral cavity (ie, sublingual and
buccal), with consideration of both systemic delivery and local therapy, is reviewed in this …

Prolonged contact time of a drug with a body tissue, through the use of a bioadhesive polymer,
can significantly improve the performance of many drugs. These improvements range …

Existing ocular drug delivery systems are fairly primitive and inefficient, but the stage is set for
the rational design of newer and significantly improved systems. The focus of this review is …

To overcome the relatively short gastrointestinal time and improve localization for oral-controlled
or sustained-release drug delivery systems, it is suggested that bioadhesive polymers …

A series of cross-linked, swellable polymers was sythesized from monomers such as acrylic
acid, methacrylic acid, and others with various cross-linking agents to produce a range of …

It has been proposed that mucoadhesives which adhere to the gastric mucus layer may be
used to prolong gastric retention time of oral dosage forms. Preliminary studies, using acrylic …

Drainage of an instilled drug solution away from the eye is responsible for a considerable
loss of drug and, hence, affects the biological activity of drugs in the eye. The rate of this …

Accessibility of the oral cavity makes it a potentially attractive route for drug delivery. However,
rapid removal of conventional delivery systems, primarily through copious salivary flow, …

Non-covalent binding of polymers to a mucin/epithelial surface has been demonstrated for a
variety of polymers on a variety of biological surfaces. Structural features of the polymer …

The intraperitoneal administration of aromatic hydrocarbons such as 3-methylcholanthrene,
b-naphthoflavone, or naphthacene induces several monooxygenase activities and the new …